Fig. 3
From: KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway
The effect of potassium on the CUL3-KLHL3-WNK4 cascade in vivo. Mice were fed with HK and LK diet and then were injected with MLN4924. Within LK groups or HK groups, the expression of pWNK4 and WNK4 increased with MLN4924 treatment. Densitometry analysis of WNK4, pWNK4, KLHL3, NEDD8, CUL3, P62, BECN1, KEAP1 and LC3B.****P <0.0001, ***P < 0.001, **P < 0.01, *P < 0.05 n=4