Rapid implementation of an emergency on-site CKRT dialysate production system during the COVID-19 pandemic

BMC Nephrology

Table 3 Prescription details of the CKRT delivered using locally produced dialysate

	No. (%)		Mean ± SD or Median [IQR] (Range)
Total no. of CKRT runs per patient^a		Mean Dose^c
1	18 (81.8%)	Dialysate (mL/h)	1800
2	1 (4.5%)	Total Therapy Fluid (mL/h)^d	2000
3	3 (13.6%)	Total Therapy Fluid/ABW (mL/kg/h)	20.0
Total no. of SCUF runs per patient^a		Total Therapy Fluid/IBW (mL/kg/h)	28.0
0	19 (86.4%)
1	2 (9.1%)	Median Prescribed Dose^c
2	1 (4.5%)	Dialysate (mL/h)	1800 [1300–2300] (1000–5000)
Anticoagulant Used^b		Total Therapy Fluid (mL/h)^d	2000 [1500–2500] (1200–5200)
None	12 (54.5%)	Total Therapy Fluid/ABW (mL/kg/h)	21.6 [17.6–25.2] (8.1–47.3)
Systemic unfractionated heparin (sUFH)	7 (31.8%)	Total Therapy Fluid/IBW (mL/kg/h)	28.8 [22.7–34.9] (14.1–69.3)
Prefilter (in-line) heparin	4 (18.2%)
Regional citrate anticoagulation (RCA)	4 (18.2%)	Duration of CKRT runs (hours)^a	55.7 [17.5–84.5] (4–312)
Simultaneous combined sUFH + RCA	4 (18.2%)

Additional Abbreviations: ABW actual body weight, CKRT continuous kidney replacement therapy, IBW ideal body weight, IQR interquartile range, SCUF slow continuous ultrafiltration, SD standard deviation
^aTreatment sessions in a patient separated by ≥ 6 h were considered separate CKRT or SCUF runs
^bIncludes all anticoagulant strategies used at any point; 6 patients were treated with 2 strategies and 1 treated with 4 different strategies; overall, at some point, 15 patients received heparin and 8 received citrate
^cMean dose was derived by taking the total volume of locally produced dialysate utilized and dividing by the total number of CKRT therapy patient-hours; median prescribed dose was derived by considering every dose adjustment as a new dose prescription, which yielded 55 distinct prescriptions
^dTotal therapy fluid includes locally produced dialysate and 200 mL/h of post-filter saline or isotonic sodium bicarbonate but excludes the contribution to total effluent dose of ultrafiltration performed for fluid removal

ISSN: 1471-2369