Rapid implementation of an emergency on-site CKRT dialysate production system during the COVID-19 pandemic

BMC Nephrology

Table 4 SOFA score components for patients treated with locally produced CKRT dialysate

Abbreviations: GCS Glasgow coma scale, IQR interquartile range, NED norepinephrine equivalent dose, P/F ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen, SD standard deviation, SOFA sequential organ failure assessment
Conversion factors for units: bilirubin in mg/dL to μmol/L, × 17.1; creatinine in mg/dL to μmol/L, × 88.4
^aP/F ratio is reported for the 19 patients with arterial blood gas available within 48 h of starting CKRT; for 2 patients, the lowest SpO2/FiO2 ratio (rather than PaO2/FiO2 ratio) in the 24 h before exposure to local dialysate was utilized to determine the respiratory sub-score as per the modified SOFA score [22]; for 2 patients on nasal oxygen, FiO2 was estimated as 4% above room air per liter per minute of flow (e.g., 3 L/min = 21 + 4*3 = 33% FiO2)
^bFor patients with total bilirubin values not available in the 24-h period before exposure, the most recent value prior to exposure was utilized
^cNorepinephrine equivalent doses of vasopressors were computed as proposed by Khanna et al. [23] to determine the cardiovascular sub-score
^dPeak serum creatinine is reported for the 15 patients not yet on CKRT at the time of initial dialysate exposure; per local charting practices, urine output was tabulated over the 24-h period ending at 7 am prior to exposure

ISSN: 1471-2369