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Fig. 1 | BMC Nephrology

Fig. 1

From: Rare case of exostosin 1/exostosin 2-related membranous lupus nephritis concomitant with dual ANCA- and anti-GBM antibody-associated crescentic glomerulonephritis effectively diagnosed by mass spectrometry: a case report

Fig. 1

Pathological findings in the present patient. a and b: Light microscopic images of renal biopsy tissue. a PAS staining (× 10). b PAM staining (× 40). c Immunofluorescence analysis of renal biopsy tissue. IgG was linear-positive for glomerular basement membrane and partially granularly positive for outer side of glomerular basement membrane. C3 and C1q were granularly positive for glomerular basement membrane. d Electron microscopic findings of renal biopsy tissue. A markedly large number of subepithelial electron-dense deposits (EDD) were observed, as well as small amount of irregular mesangial EDD. Basement membrane was thickened. e Mass spectrometry analysis using glomeruli from formalin fixed paraffin embedded tissue section by laser microdissection. Exostosin 1 and 2 were detected (red outlines). PAS, Periodic Acid Schiff; PAM, Periodic Acid-Methenamine silver

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BMC Nephrology

ISSN: 1471-2369

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