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Table 3 Sensitivity and specificity values of serological and immunohistological examinations for the detection of pMN

From: The value of PLA2R antigen and IgG subclass staining relative to anti-PLA2R seropositivity in the differential diagnosis of membranous nephropathy

 

Sensitivity (%)

Specificity (%)

Anti-PLA2R seropositivity

61.1

90.0

PLA2R antigen staining

81.0

66.7

IgG4-dominance

52.2

91.7

IgG4-dominance/codominance with any other IgG subtype

92.1

70.8

IgG4-dominance/IgG1-IgG4-codominance

64.2

75.0

IgG4-dominance/IgG3-IgG4 codominance

76.2

87.5