Predictive value of glycemic gap and stress glycemia ratio among critically ill patients with acute kidney injury: a retrospective analysis of the MIMIC-III database

Table 3 Prognostic effect of glycemic parameters on the risk of ICU outcomes

	Crude OR (95% CI)	P value	Adjusted OR (95% CI)	P value	AUC (95% CI)	P value
RRT
Hypoglycemia	2.95 (1.43, 6.08)	0.002	1.95 (0.70, 3.45)	0.204	0.52 (0.49, 0.56)	0.142
Hyperglycemia	1.21 (0.97, 1.51)	0.089	0.76 (0.56, 1.02)	0.070	0.51 (0.48, 0.54)	0.530
Acute glycemia	1.02 (0.99, 1.04)	0.091	0.93 (0.82, 1.25)	0.287	0.52 (0.49, 0.55)	0.223
Chronic glycemia	0.93 (0.88, 0.97)	0.002	1.10 (0.81, 1.49)	0.550	0.44 (0.40, 0.47)	< 0.001
Glycemic gap	1.39 (1.17, 1.66)	< 0.001	1.00 (0.99, 1.00)	0.160	0.56 (0.53, 0.59)	< 0.001
SHR	1.01 (1.00, 1.01)	0.001	0.92 (0.75, 1.12)	0.405	0.55 (0.52, 0.59)	0.001
ICU mortality
Hypoglycemia	1.83 (0.75, 4.49)	0.187	1.68 (0.65, 4.33)	0.283	0.51 (0.47, 0.54)	0.784
Hyperglycemia	1.94 (1.49, 2.53)	< 0.001	1.92 (1.45, 2.56)	< 0.001	0.58 (0.55, 0.62)	< 0.001
Acute glycemia	1.04 (1.02, 1.06)	0.001	1.18 (0.89, 1.56)	0.244	0.59 (0.55, 0.62)	< 0.001
Chronic glycemia	0.98 (0.93, 1.03)	0.482	1.00 (0.94, 1.06)	0.915	0.48 (0.45, 0.52)	0.378
Glycemic gap	1.50 (1.23, 1.82)	< 0.001	1.00 (1.00, 1.01)	0.019	0.60 (0.56, 0.63)	< 0.001
SHR	1.01 (1.00, 1.02)	< 0.001	1.30 (1.05, 1.61)	0.018	0.60 (0.56, 0.63)	< 0.001

OR was adjusted for age, gender, ethnicity, ICU admission, AKI stage, SAPSII, insulin administration, eGFR values and ICU mortality in the multivariate model
ICU Intensive care unit, SHR Stress hyperglycemia ratio, eGFR estimated glomerular filtration rate, RRT Renal replacement therapy, SAPS II Simplified acute physiology score II, OR Odds ratio, CI Confidence interval

ISSN: 1471-2369