Fig. 2
From: Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort
Longitudinal trajectories* of estimated glomerular filtration rate (eGFR) according to time of use of proton pump inhibitors (PPI). ELSA-Brasil (2008–2010 and 2012–2014). *As age was modeled as a random effect in the data analysis, this figure shows changes in estimated glomerular filtration rate over time (i.e., as individuals age). †Predicted numbers are dependent variable values based on estimated regression coefficients and a prediction of independent variable values after adjustments (age, sex, per capita household income, excessive alcohol consumption, obesity, cardiovascular disease, diabetes, hypertension, use of NSAIDs, BRAs, ACEs and interaction: time of PPI use × age)