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Table 3 Association between the use of proton pump inhibitors and incident chronic kidney disease. ELSA-Brasil. (N = 13,301)

From: Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort

Models

Total

N = 13,301

(100%)

Incident CKD

N = 509

(3.8%)

Reference

OR (95%CI)

Model 0 π

  

1

1.85 (1.41–2.41)*

Model 1†

  

1

1.36 (1.03–1.80)*

Model 2‡

  

1

1.35 (1.02–1.79)*

Model 3£

  

1

1.31 (0.98–1.74)

Model 4§

  

1

1.29 (0.97–1.71)

  1. π Model 0: not adjusted.
  2. † Model 1: adjusted for age, sex and per capita household income.
  3. ‡ Model 2: adjusted by model 1 + excessive alcohol consumption, smoking and obesity.
  4. £ Model 3: adjusted by model 2 + cardiovascular disease, diabetes and hypertension.
  5. § Model 4: adjusted by model 3 + use of NSAIDs, ARBs and ACEs.
  6. * p < 0.05.
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BMC Nephrology

ISSN: 1471-2369

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