From: Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort
PPI use time | Number incident CKD eventsϋ | Reference¥ | Model 0 π HR (95%CI) | Model 1† HR (95%CI) | Model 2‡ HR (95%CI) | Model 3£ HR (95%CI) | Model 4§ HR (95%CI) |
---|---|---|---|---|---|---|---|
Up to 6 months | 5 | 1 | 0.85 (0.35–2.09) | 0.75 (0.30–1.86) | 0.77 (0.31–1.91) | 0.74 (0.30–1.86) | 0.74 (0.30–1.86) |
Over 6 months | 44 | 1 | 2.33 (1.69–3.22)* | 1.48 (1.05–2.07)* | 1.46 (1.04–2.04)* | 1.42 (1.01–2.00)* | 1.39 (0.99–1.96) |