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Table 7 Association of duration of proton pump inhibitor use and change in glomerular filtration rate estimated by mixed-effect linear regression. ELSA-Brasil (N = 13,606)

From: Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort

Variable

Estimated glomerular filtration rate (eGFR)

β (95%CI)

Intercept

124.148 (122.764 ; 125.532)*

PPI use time up to

6 months

10.590 (1.814 ; 20.365)*

Over 6 months

8.297 (2.387 ; 14.206)*

Age† (years)

-0.754 (-0.777 ; -0.731)*

Time of use PPI b x Age†

 

Up to 6 months

-0.196 (-0.370 ; -0.021)*

Over 6 months

-0.149 (-0.248 ; -0.049)*

  1. b Reference: Non PPI users.
  2. *β; p < 0.05.
  3. † Age (age at baseline + segment time) was modeled as a random effect to index time.
  4. Final model adjusted for: age†, sex, per capita household income, excessive alcohol consumption, smoking, obesity, cardiovascular disease, diabetes, hypertension, NSAIDs, ARBs and ACEs use.
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BMC Nephrology

ISSN: 1471-2369

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