Table 1 Baseline characteristics

Man/woman (n/%)

50/29 (63/37)

31/19 (62/38)

NS

37/25 (60/40)

13/4 (76/24)

NS

Age (year)

46.3 ± 11.2

45.8 ± 12.8

NS

43.8 ± 11.2

55.5 ± 7.7

< 0.001

Average systolic/diastolic RR (Hgmm)

122/73 ± 14/9

127/76 ± 13/9

0.04

120/72 ± 11/8

129/76 ± 16/9

0.014

24 h pulse pressure (Hgmm)

49.2 ± 10.7

51.2 ± 9.3

NS

48.3 ± 12.8

53.7 ± 7.7

0.048

Diurnal index systolic (%)

10.67 ± 5.6

9.1 ± 5.5

NS

11.7 ± 6.2

7.2 ± 5.2

0.004

Metabolic parameters

Hypertension (n, %)

60 (76)

31 (62)

0.045

43 (69)

17 (100)

0.004

BMI (kg/m2)

28.1 ± 4.8

27.9 ± 5.1

NS

26 ± 4.7

28.4 ± 4.5

0.015

Dyslipidaemia (n, %)

36 (46)

26 (52)

NS

26 (42)

10 (59)

NS

Diabetes (n, %)

25 (32)

17 (34)

NS

17 (27)

8 (47)

NS

eGFR (ml/min)

87.2 ± 32.4

107.4 ± 18.3

< 0.001

98.2 ± 27.8

39.7 ± 29.6

< 0.001

Duration of kidney disease (year)

10.8 ± 9.4

-

-

10 ± 9

11.5 ± 10

NS

Smoking (n, %)

14 (18)

10 (20)

NS

10 (16)

4 (23)

NS

Metabolic syndrome (n, %)

22 (28)

15 (30)

NS

14 (22)

8 (47)

0.023

ASCVD risk score (%)

6.49

7.37

NS

4.63

7.10

NS

Arterial stiffness parameters

Stiffness index (SI, m/s)

10.3 ± 2.59

8.88 ± 2.2

< 0.001

9.99 ± 2.13

10.97 ± 2.29

0.045

Pulse wave velocity (PWVao, m/s)

9.89 ± 1.65

8.6 ± 1.5

< 0.001

9.71 ± 1.61

10.72 ± 1.61

0.029

Aortic systolic blood pressure

(SBPao, Hgmm)

121.1 ± 18.3

122.0 ± 19.3

NS

119.5 ± 16.4

127.9 ± 23.9

NS

Augmentation index (Aix)

-20.3 ± 29.0

-30.4 ± 28.2

0.049

-21.9 ± 29.9

-13.4 ± 23.6

NS

Echocardiographic parameters

LVEF (%)

62.4 ± 6.5

63.4 ± 6.9

NS

62.2 ± 4.9

63.1 ± 7.7

NS

LVMI

106.6 ± 22.8

108.67 ± 21.1

NS

101.5 ± 16

125.2 ± 23

< 0.001

LVM (g)

204.4 ± 51.4

200.5 ± 49.1

NS

194.9 ± 44.0

239.0 ± 48.8

< 0.001

LVEDD (cm)

4.95 ± 0.4

4.83 ± 0.4

NS

4.93 ± 0.39

5.05 ± 0.41

NS

DD (n/%)

37 (47)

20 (40)

NS

24 (39)

13 (76)

0.003

E/A

1.05 ± 0.33

1.07 ± 0.38

NS

1.11 ± 0.32

0.85 ± 0.24

< 0.001

EDT (ms)

192 ± 40.6

186.7 ± 40.4

NS

185.8 ± 33.8

215.3 ± 43.5

0.003

Ea (cm/s)

13.2 ± 3.69

13.3 ± 5.0

NS

14.0 ± 2.13

10.5 ± 2.08

< 0.001

Aa (cm/s)

11.3 ± 3.0

11.1 ± 3.0

NS

11.0 ± 3.41

12.3 ± 2.63

NS

Ea/Aa

1.28 ± 0.57

1.32 ± 0.69

NS

1.38 ± 0.54

0.91 ± 0.32

< 0.001

E/Ea

4.88 ± 1.31

4.08 ± 1.54

NS

4.72 ± 0.95

5.43 ± 1.40

0.024

LVR

0.94 ± 0.25

1.04 ± 0.33

NS

0.94 ± 0.24

0.97 ± 0.26

0.035

Laboratory results

Hb (g/dl)

13.6 ± 1.53

13.8 ± 1.42

NS

13.8 ± 1.56

13.1 ± 1.54

NS

MAU (mg/day)

484.6 ± 658.4

35.9 ± 30.9

< 0.001

420.8 ± 550.9

717.3 ± 721.8

0.016

HUS (umol/l)

320.5 ± 76.7

315.4 ± 65.8

NS

307.9.4 ± 76.7

366.8 ± 68.8

0.015

Total cholesterol (mmol/l)

5.03 ± 1.21

4.95 ± 1.20

NS

5.05 ± 0.95

5.16 ± 1.41

NS

HDL cholesterol (mmol/l)

1.28 ± 0.51

1.25 ± 0.45

NS

1.32 ± 0.64

1.15 ± 0.36

NS

TG (mmol/l)

1.69 ± 1.05

1.86 ± 1.10

NS

1.60 ± 0.90

2.00 ± 1.12

NS

Therapy

ACEI/ARB (n, %)

65 (82)

27 (54)

0.003

45 (72)

14 (82)

NS

BB (n, %)

22 (28)

19 (38)

NS

10 (16)

3 (18)

NS

Statin (n, %)

26 (33)

21 (42)

NS

12 (19)

4 (23)

NS

CCB (n, %)

22 (28)

17 (34)

NS

12 (19)

4 (23)

NS