Table 2 Probability of Target Attainment and Predicted AUC24h of Simulated Vancomycin Dosing Regimens in 3-h Home Hemodialysis Schedule
PTA (%) (percentage of simulated patients attaining AUC 24 h < 400 / 400–600 / > 600 mg∙h/L) AUC24h mg∙h/L, Mean ± SD | |||||||
|---|---|---|---|---|---|---|---|
Vancomycin Dosing | Day 1 (Mon) | Day 2 (Tue) | Day 3 (Wed) | Day 4 (Thu) | Day 5 (Fri) | Day 6 (Sat) | Day 7 (Sun) |
3-h HHD 5 days per week with a total dialysate volume of 20 L (Qd = 6.7 L/hr) | |||||||
25–5-5–5-7.5 mg/kg post-HHD | 96 (4/30/66) 708 ± 218 | 98 (2/22/76) 749 ± 199 | 99 (1/20/79) 747 ± 182 | 99 (1/19/80) 747 ± 173 | 100 (0/10/90) 831 ± 191 | 99 (1/18/82) 764 ± 181 | 98 (2/29/69) 693 ± 170 |
25–0-5–0-7.5 mg/kg post-HHDa | 98 (4/29/67) 713 ± 220 | 92 (8/46/46) 600 ± 159 | 95 (5/41/54) 703 ± 155 | 82 (18/63/19) 562 ± 118 | 97 (3/41/56) 682 ± 148 | 93 (7/52/41) 628 ± 142 | 86 (14/60/26) 570 ± 131 |
25–0-7.5–0-7.5 mg/kg post-HHDa | 95 (5/29/66) 712 ± 226 | 91 (9/45/46) 600 ± 161 | 91 (2/28/70) 703 ± 177 | 99 (9/56/35) 562 ± 131 | 96 (1/31/68) 682 ± 159 | 96 (4/42/54) 628 ± 150 | 91 (10/53/38) 570 ± 140 |
25–0-10–0-10 mg/kg post-HHDa | 96 (9/45/46) 712 ± 218 | 92 (9/45/46) 600 ± 156 | 99 (1/17/82) 779 ± 192 | 96 (4/43/53) 623 ± 141 | 100 (1/12/87) 807 ± 185 | 99 (1/21/78) 743 ± 175 | 98 (2/33/65) 674 ± 164 |
3-h HHD 5 days per week with a total dialysate volume of 30 L (Qd = 10 L/hr) | |||||||
25–5-5–5-7.5 mg/kg post-HHD | 95 (5/28/67) 713 ± 223 | 98 (2/24/73) 729 ± 192 | 98 (2/26/72) 709 ± 170 | 99 (1/28/71) 697 ± 161 | 100 (0/16/84) 774 ± 178 | 99 (1/26/73) 712 ± 169 | 97 (3/40/57) 645 ± 158 |
25–0-7.5–0-7.5 mg/kg post-HHDa | 95 (5/29/66) 710 ± 220 | 90 (10/51/39) 574 ± 145 | 98 (3/34/63) 665 ± 158 | 84 (16/63/21) 512 ± 115 | 97 (3/43/54) 628 ± 140 | 93 (7/54/39) 579 ± 133 | 84 (16/59/25) 524 ± 125 |
25–0-10–0-10 mg/kg post-HHDa | 96 (4/30/66) 713 ± 222 | 90 (10/51/39) 575 ± 146 | 99 (1/22/77) 741 ± 180 | 93 (7/56/37) 570 ± 130 | 100 (0/19/81) 750 ± 171 | 99 (2/29/69) 691 ± 162 | 96 (4/43/53) 625 ± 151 |
3-h HHD 4 days per week with a total dialysate volume of 30 L (Qd = 10 L/hr) | |||||||
20–5-5–5 mg/kg post-HHD | 88 (12/45/43) 592 ± 179 | 94 (6/41/53) 627 ± 163 | 89 (11/52/37) 570 ± 148 | 93 (7/51/42) 586 ± 141 | 96 (4/48/48) 609 ± 142 | 91 (9/57/34) 560 ± 134 | 81 (19/60/21) 507 ± 125 |
20–5-5–7.5 mg/kg post- HHD | 88 (12/45/43) 590 ± 175 | 94 (5/41/53) 625 ± 161 | 89 (11/51/28) 569 ± 147 | 93 (7/50/43) 585 ± 140 | 98 (2/30/68) 685 ± 161 | 96 (4/42/54) 630 ± 152 | 90 (10/52/38) 571 ± 142 |
25–5-5–5 mg/kg post- HHD | 95 (5/29/66) 714 ± 223 | 98 (2/24/74) 737 ± 194 | 96 (4/33/63) 670 ± 177 | 97 (3/35/62) 663 ± 159 | 98 (2/33/65) 669 ± 154 | 95 (5/46/49) 615 ± 146 | 89 (11/55/34) 557 ± 136 |
25–5-5–7.5 mg/kg post-HHD | 96 (4/30/66) 709 ± 223 | 98 (2/24/74) 732 ± 192 | 96 (4/35/61) 664 ± 175 | 97 (3/36/61) 657 ± 157 | 99 (1/20/79) 740 ± 171 | 98 (2/32/66) 680 ± 162 | 95 (5/45/50) 616 ± 151 |
3-h HHD 4 days per week with a total dialysate volume of 40 L (Qd = 13.3 L/hr) | |||||||
20–5-5–5 mg/kg post- HHD | 89 (12/46/42) 591 ± 174 | 94 (6/45/49) 612 ± 152 | 88 (12/55/33) 555 ± 139 | 91 (9/56/35) 562 ± 131 | 94 (6/55/39) 578 ± 131 | 87 (13/61/26) 532 ± 124 | 75 (25/61/14) 481 ± 116 |
20–5-5–7.5 mg/kg post- HHD | 87 (13/46/41) 585 ± 174 | 93 (7/46/47) 606 ± 154 | 87 (13/54/33) 551 ± 141 | 90 (10/56/34) 558 ± 133 | 98 (2/38/60) 650 ± 152 | 94 (6/48/46) 600 ± 145 | 86 (14/56/30) 542 ± 135 |
25–5-5–5 mg/kg post- HHD | 95 (5/29/66) 712 ± 222 | 98 (2/26/72) 717 ± 184 | 96 (4/37/59) 650 ± 167 | 97 (3/42/55) 631 ± 148 | 97 (3/43/54) 630 ± 144 | 93 (7/53/40) 580 ± 136 | 84 (16/59/25) 525 ± 127 |
25–5-5–7.5 mg/kg post-HHD | 95 (5/30/65) 704 ± 218 | 98 (2/27/71) 709 ± 181 | 96 (5/39/57) 643 ± 165 | 97 (4/44/53) 625 ± 146 | 99 (1/28/71) 700 ± 159 | 97 (3/40/57) 644 ± 151 | 93 (7/52/41) 582 ± 141 |
3-h HHD 4 days per week with a total dialysate volume of 50 L (Qd = 16.7 L/hr) | |||||||
20–5-5–5 mg/kg post- HHD | 88 (12/46/42) 587 ± 176 | 93 (7/47/46) 598 ± 149 | 86 (14/56/30) 542 ± 135 | 89 (11/59/30) 544 ± 126 | 91 (9/57/34) 557 ± 127 | 83 (17/62/21) 512 ± 120 | 69 (31/58/11) 463 ± 112 |
20–5-5–7.5 mg/kg post- HHD | 88 (12/45/43) 590 ± 176 | 93 (7/47/46) 601 ± 151 | 86 (14/55/31) 545 ± 138 | 89 (11/59/30) 546 ± 129 | 97 (3/51/42) 636 ± 148 | 93 (7/51/42) 586 ± 140 | 85 (15/59/26) 529 ± 130 |
25–5-5–5 mg/kg post- HHD | 95 (5/30/65) 703 ± 219 | 97 (3/28/69) 698 ± 178 | 95 (5/40/55) 633 ± 162 | 95 (5/46/49) 609 ± 143 | 95 (5/48/47) 604 ± 139 | 90 (10/57/33) 556 ± 131 | 79 (21/60/19) 502 ± 123 |
25–5-5–7.5 mg/kg post-HHD | 96 (4/30/66) 707 ± 216 | 98 (2/28/70) 703 ± 176 | 96 (4/40/56) 638 ± 161 | 96 (4/46/50) 614 ± 143 | 99 (1/30/69) 687 ± 157 | 97 (3/42/55) 633 ± 149 | 91 (9/54/37) 571 ± 139 |