Table 3 Probability of Target Attainment and Predicted AUC_24h of Simulated Vancomycin Dosing Regimens in 7-h Home Hemodialysis Schedule

7-h HHD 5 days per week with a total dialysate volume of 30 L (Qd = 4.3 L/hr)

 25–5-5–5-5 mg/kg post-HHD

95 (5/31/64)

693 ± 210

97 (3/32/65)

673 ± 164

97 (3/56/41)

633 ± 142

96 (4/48/48)

608 ± 135

96 (4/48/48)

610 ± 137

91 (9/57/34)

561 ± 129

79 (21/60/19)

498 ± 119

 25–5-5–5-7.5 mg/kg post-HHD

95 (5/32/63)

686 ± 204

97 (3/33/64)

669 ± 162

97 (3/42/55)

630 ± 142

96 (4/48/48)

606 ± 136

99 (1/31/68)

684 ± 153

97 (3/42/55)

630 ± 145

90 (10/56/34)

559 ± 133

 25–5-5–5-10 mg/kg post-HHD

95 (5/32/63)

691 ± 210

97 (3/32/65)

673 ± 165

97 (3/41/56)

633 ± 143

96 (4/46/50)

609 ± 136

100 (0/16/84)

765 ± 170

99 (1/26/73)

706 ± 161

96 (4/42/54)

626 ± 147

 25–7.5–7.5–7.5–10 mg/kg post-HHD

95 (5/32/63)

688 ± 211

99 (1/21/78)

743 ± 185

100 (0/18/82)

757 ± 173

100 (0/16/84)

771 ± 173

100 (0/5/95)

885 ± 199

100 (0/12/88)

815 ± 189

99 (1/24/75)

723 ± 173

7-h HHD 5 days per week with a total dialysate volume of 60 L (Qd = 8.6 L/hr)

 25–5-5–5-5 mg/kg post-HHD

94 (6/33/61)

680 ± 203

95 (5/49/46)

599 ± 136

88 (12/62/26)

530 ± 118

78 (22/62/16)

490 ± 114

93 (7/57/36)

565 ± 126

86 (14/62/24)

522 ± 119

67 (33/57/10)

456 ± 109

 25–5-5–5-7.5 mg/kg post-HHD

95 (5/33/62)

676 ± 200

98 (2/33/65)

668 ± 152

98 (2/38/60)

646 ± 140

97 (3/40/57)

636 ± 141

98 (2/35/63)

662 ± 148

96 (4/46/50)

610 ± 140

86 (14/58/28)

534 ± 129

 25–5-5–5-10 mg/kg post-HHD

95 (5/32/63)

683 ± 200

98 (2/31/67)

675 ± 152

98 (2/37/61)

652 ± 141

98 (2/40/58)

642 ± 142

100 (0/19/81)

745 ± 162

99 (1/30/69)

688 ± 153

95 (5/49/46)

601 ± 140

7-h HHD every other day with a total dialysate volume of 30 L (Qd = 4.3 L/hr)

 20 mg/kg LD, 7.5 mg/kg post-HD

89 (11/46/43)

596 ± 182

83 (17/50/33)

550 ± 163

95 (5/42/53)

633 ± 164

89 (11/53/36)

565 ± 145

97 (3/39/58)

648 ± 157

92 (8/52/40)

579 ± 142

98 (2/36/62)

661 ± 158

 25 mg/kg LD, 5 mg/kg post-HD

95 (5/28/67)

716 ± 220

94 (6/33/61)

676 ± 202

96 (4/38/58)

649 ± 162

91 (9/51/40)

577 ± 143

93 (7/52/41)

581 ± 134

84 (16/61/23)

518 ± 122

89 (11/61/28)

540 ± 124

 25 mg/kg LD, 7.5 mg/kg post-HHD

96 (4/28/68)

717 ± 219

95 (5/33/62)

677 ± 200

98 (2/24/74)

725 ± 181

96 (4/37/59)

646 ± 160

99 (1/26/73)

707 ± 164

96 (4/41/55)

630 ± 148

99 (1/27/72)

698 ± 160

7-h HHD every other day with a total dialysate volume of 50 L (Qd = 7.1 L/hr)

 20 mg/kg LD, 7.5 mg/kg post-HHD

89 (11/45/46)

602 ± 182

84 (16/51/33)

549 ± 159

94 (6/48/46)

601 ± 145

86 (14/60/26)

530 ± 127

95 (5/51/44)

594 ± 135

86 (14/61/25)

525 ± 122

95 (5/52/43)

594 ± 134

 25 mg/kg LD, 5 mg/kg post-HHD

96 (4/28/68)

718 ± 225

94 (6/34/60)

670 ± 200

95 (5/48/47)

603 ± 142

86 (14/60/26)

530 ± 124

85 (15/64/21)

516 ± 114

68 (32/59/9)

456 ± 104

73 (27/62/11)

469 ± 105

 25 mg/kg LD, 7.5 mg/kg post-HHD

95 (5/28/67)

719 ± 228

94 (6/34/60)

671 ± 204

98 (2/32/66)

681 ± 167

94 (6/48/46)

600 ± 146

97 (3/39/58)

641 ± 147

91 (9/55/36)

566 ± 132

96 (4/44/52)

621 ± 142

7-h HHD every other day with a total dialysate volume of 60 L (Qd = 8.6 L/hr)

 20 mg/kg LD, 7.5 mg/kg post-HHD

89 (11/45/44)

598 ± 179

83 (17/51/32)

543 ± 155

93 (7/52/41)

583 ± 139

83 (17/61/22)

512 ± 122

93 (7/57/36)

569 ± 130

81 (19/62/19)

501 ± 117

92 (8/57/35)

565 ± 129

 25 mg/kg LD, 5 mg/kg post-HHD

95 (5/29/66)

714 ± 225

94 (6/36/58)

663 ± 199

93 (7/52/41)

584 ± 138

83 (17/61/22)

512 ± 121

79 (21/63/16)

493 ± 112

60 (40/53/7)

434 ± 102

64 (36/56/8)

445 ± 103

 25 mg/kg LD, 7.5 mg/kg post-HHD

95 (5/28/67)

714 ± 226

93 (7/34/59)

664 ± 200

97 (3/34/63)

660 ± 156

92 (8/52/40)

580 ± 136

96 (4/46/50)

614 ± 136

89 (11/60/29)

541 ± 122

95 (5/51/44)

592 ± 131

 25 mg/kg LD, 10 mg/kg post-HHD

96 (4/29/67)

717 ± 222

94 (6/35/59)

666 ± 196

99 (1.21/78)

739 ± 176

97 (3/38/59)

650 ± 153

99 (1/20/79)

737 ± 165

98 (2/38/60)

649 ± 148

99 (1/19/80)

741 ± 165