Table 4 Optimal Vancomycin and Daptomycin Dosing Regimens in Ten Home Hemodialysis settings
HHD Regimen | Vancomycin Dosing Regimen | Daptomycin Dosing Regimen | |||
|---|---|---|---|---|---|
Duration (Hours/ session) | Frequency (Days/week) | Dialysate Volume (L/session) | Initial Dosing Regimen | TDM strategy after the initial dosing regimen | |
3 | 5 (M-T-W-Th-F) | 20 | 25–0-7.5–0-7.5 mg/kg post-HHDa | 1) Draw pre-HHD level prior to the last HHD of the week (i.e. Friday) 2) Adjust the dose using the equation below: \(\text{New MD (mg/kg) = }\frac{\text{Previous MD x 24 mg/L}}{\text{Pre-HHD vancomycin conc.}}\)  | 4 mg/kg post-HHD, with 2 mg/kg supplemental dose on the 3rd day of 3-day interdialytic period |
30 | 25–0-10–0-10 mg/kg post-HHDa | ||||
3¶ | 4 (M-T-Th-F) | 30 | 25–5-5–7.5 mg/kg post-HHD | ||
40 | |||||
50 | |||||
7¶ | 5 (M-T-W-Th-F) | 30 | 25–5-5–5-7.5 mg/kg post-HHD | ||
60 | 25–7.5–7.5–7.5–10 mg/kg post-HHD | ||||
7 | 3.5 (M-W–F-Sun) | 30 | 25 mg/kg, 7.5 mg/kg post-HHD | 6 mg/kg post-HHD | |
50 | |||||
60 | |||||