Risk factors associated with acute kidney injury in a pediatric intensive care unit in Addis Ababa Ethiopia: case-control study

Table 4 Risk factors associated with AKI among critically ill children admitted to PICU at TASH, Addis Ababa, Ethiopia. (n = 241)

Variable	AKI		COR (95% CI)	AOR (95% CI)	P- value
Variable	Cases	Controls	COR (95% CI)	AOR (95% CI)	P- value
Sepsis or infection
Yes	26	18	3.73(1.89 34)	3.37 (1.42–7.99)	0.006
No	55	142	1	1
Hypertension
Yes	25	15	4.32(2.12–8.78)	5.36 (2.06–13.93)	0.001
No	56	145	1	1
Heart failure
Yes	11	9	2.637(1.05–6.65)	1.69 (0.44–6.44)	0.443
No	70	151	1	1
Hypovolemic Shock
Yes	51	48	3.967(2.26–6.97)	3.876(1.85–8.12)	0.000
No	30	112	1	1
Exposure to Nephrotoxic drugs*
Yes	18	13	3.23 (1.49–6.99)	4.09 (1.45–11.59)	0.008
No	63	147	1.00	1
Exposure to Herbal medication
Yes	29	18	4.40 (2.25–8.58)	2.38 (0.95–5.92)	0.063
No	52	142	1	1
Mechanical ventilation
Yes	52	64	2.69 (1.55–4.68)	2.25 (1.12–4.51)	0.023
No	29	96	1	1
Systemic lupus Erythematous
Yes	14	6	5.36 (1.97–14.56)	3.26 (0.80–13.32)	0.100
No	67	154	1	1
Electrolyte Abnormality
Yes	16	16	2.22(1.044 4.70)	1.66 (0.60–4.59)	0.325
No	65	144	1	1
Nephrotic- syndrome
Yes	14	9	3.50 (1.45–8.50)	1.56 (0.48–5.06)	0.460
No	67	151	1	1
Nephritic syndrome
Yes	23	15	3.83 (1.87–7.86)	2.97 (1.19–7.43)	0.020
No	58	145	1	1

AKI; Acute Kidney Injury; AOR, Adjusted Odds Ratio; COR, Crude Odds Ratio; CI, Confidence interval; *exposure to nephrotoxic drugs (aminoglycoside, vancomycin, nonsteroidal anti-inflammatory drug, radiologic contrast)

ISSN: 1471-2369