Association between nutritional status scores and the 30-day mortality in patients with acute kidney injury: an analysis of MIMIC-III database

Table 3 Association between PNI and GNRI and 30-day mortality and in age, SOFA, and SAPS-II subgroups

Subgroups	Variables	Model 1		Model 2		Model 3
Subgroups	Variables	h (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
	PNI¹	0.51 (0.39–0.68)	< 0.001	0.48 (0.37–0.64)	< 0.001	0.71 (0.51–0.98)	0.036
	GNRI²	0.49 (0.38–0.64)	< 0.001	0.47 (0.36–0.61)	< 0.001	0.63 (0.47–0.86)	0.003
Age < 65	PNI¹	0.54 (0.35–0.83)	0.005	0.49 (0.31–0.75)	0.001	1.14 (0.67–1.96)	0.622
Age < 65	GNRI²	0.47 (0.31–0.72)	< 0.001	0.43 (0.28–0.66)	< 0.001	1.07 (0.65–1.75)	0.793
Age ≥ 65	PNI¹	0.50 (0.35–0.71)	< 0.001	0.48 (0.34–0.69)	< 0.001	0.54 (0.35–0.82)	0.004
Age ≥ 65	GNRI²	0.50 (0.35–0.70)	< 0.001	0.48 (0.34–0.68)	< 0.001	0.51 (0.34–0.76)	< 0.001
SOFA < 6	PNI¹	0.38 (0.21–0.67)	< 0.001	0.36 (0.20–0.65)	< 0.001	0.38 (0.18–0.81)	0.012
SOFA < 6	GNRI²	0.57 (0.34–0.96)	0.035	0.52 (0.31–0.89)	0.016	0.57 (0.28–1.14)	0.110
SOFA ≥ 6	PNI¹	0.69 (0.50–0.94)	0.021	0.67 (0.49–0.92)	0.013	0.80 (0.55–1.15)	0.223
SOFA ≥ 6	GNRI²	0.57 (0.42–0.78)	< 0.001	0.56 (0.41–0.77)	< 0.001	0.65 (0.46–0.93)	0.018
SAPS-II < 43	PNI¹	0.30 (0.17–0.53)	< 0.001	0.25 (0.14–0.45)	< 0.001	0.22 (0.11–0.46)	< 0.001
SAPS-II < 43	GNRI²	0.62 (0.36–1.08)	0.090	0.52 (0.29–0.90)	0.021	0.62 (0.32–1.22)	0.169
SAPS-II ≥ 43	PNI¹	0.79 (0.58–1.09)	0.148	0.81 (0.59–1.13)	0.212	0.89 (0.62–1.28)	0.521
SAPS-II ≥ 43	GNRI²	0.61 (0.45–0.84)	0.002	0.63 (0.46–0.87)	0.005	0.63 (0.44–0.88)	0.008

PNI: prognostic nutritional index, GNRI: geriatric nutritional risk index, SOFA: sequential organ failure assessment, SAPS-II: simplified acute physiology score II, HR: hazard ratio, CI: confidence interval
1: PNI ≥ 28.5
2: GNRI ≥ 83.25
Model 1 was the crude model;
Model 2 adjusted for age, gender, and race;
Model 3 adjusted for age, gender, and race mechanical ventilation use, vasopressors use, AKI stage, ICU length of stay, CCI, SOFA, SAPS-II, HB, RDW, AG, eGFR, SpO2, NLR, PT, GCS, INR, and RR.
Notes: the variables to classify subgroup were not adjusted in its subgroup

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