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Table 1 Baseline characteristics of different categories HVS in peritoneal dialysis patients with diabetes

From: Visit-to-visit HbA1c variability is associated with poor prognosis in peritoneal dialysis patients with type 2 diabetes mellitus

 

All patients

(n = 820)

HVS < 1/3

(n = 428)

1/3 ≤ HVS < 2/3

(n = 254)

HVS ≥ 2/3

(n = 138)

p for tend

Age (years)

56.9 ± 14.6

55.8 ± 14.9

58.2 ± 14.2

60.1 ± 13.7

 < 0.001

Sex, Male, n (%)

424 (51.7)

224 (52.3)

130 (51.2)

70 (50.2)

0.706

Smoking, n (%)

204 (24.6)

102 (23.8)

64 (25.2)

38 (27.5)

0.381

Drinking, n (%)

112 (13.7)

54 (12.6)

36 (14.2)

22 (15.9)

0.328

Cardiovascular disease history, n (%)

266 (32.4)

136 (31.8)

90 (35.4)

40 (28.9)

0.848

Hypertension, n (%)

670 (81.7)

354 (82.7)

202 (79.5)

114 (82.6)

0.714

Drugs

 Insulin, n (%)

686 (83.7)

362 (84.6)

212 (83.5)

112 (81.2)

0.353

 Statins, n (%)

178 (21.7)

98 (22.9)

52 (20.5)

28 (20.3)

0.427

 Antiplatelet, n (%)

250 (30.5)

112 (29.0)

92 (36.2)

34 (24.6)

0.527

 Hypertensive agent, n (%)

666 (81.2)

340 (79.4)

214 (84.3)

112 (81.2)

0.370

Mean arterial pressure (mmHg)

97.2 ± 12.1

96.6 ± 11.8

97.3 ± 12.0

97.8 ± 12.9

0.547

Body mass index (kg/m2)

21.9 ± 3.5

21.6 ± 3.3

22.2 ± 3.6

22.8 ± 4.1

0.010

Mean time of diabetes history (years)

15.5 ± 6.7

15.2 ± 5.1

15.6 ± 5.8

16.0 ± 7.1

0.153

Frequencies of HbA1c measurement (per patient)

5.5 (4.6, 7.0)

5.6 (4.3, 7.2)

5.3 (4.2, 7.1)

5.2 (4.0, 6.4)

0.109

HbA1c at baseline (%)

7.0 ± 2.3

6.8 ± 2.1

7.4 ± 2.8

8.0 ± 3.2

 < 0.001

HbA1c at baseline (mmol/mol)

53.0 ± 24.6

51.1 ± 23.0

57.7 ± 30.2

64.3 ± 35.1

 < 0.001

Fasting blood-glucose (mmol/L)

8.1 ± 2.7

7.8 ± 2.5

8.0 ± 2.8

8.2 ± 3.1

0.146

Hemoglobin (g/L)

90.6 ± 10.4

88.8 ± 10.1

90.1 ± 10.5

92.3 ± 9.8

 < 0.001

Alanine aminotransferase (U/L)

23.2 ± 8.0

22.9 ± 8.1

23.5 ± 7.8

24.1 ± 8.6

0.072

Serum albumin (g/L)

35.0 ± 5.3

34.9 ± 5.1

35.0 ± 5.4

34.8 ± 5.2

0.807

High-density lipoprotein (mmol/L)

1.4 ± 0.4

1.4 ± 0.4

1.4 ± 0.5

1.4 ± 0.5

0.143

Low-density lipoprotein (mmol/L)

3.1 ± 1.2

3.0 ± 0.9

3.1 ± 1.1

3.2 ± 1.4

0.072

Intact parathyroid hormone (pg/ml)

250 ± 110

254 ± 109

246 ± 127

259 ± 104

0.953

Residual renal function (ml/min)

3.8 (1.2, 9.2)

3.7 (1.1, 7.1)

3.8 (1.6, 9.9)

3.9 (1.8, 10.4)

0.095

C-reactive protein (mg/L)

5.9 (4.3, 8.0)

5.8 (4.2, 7.5)

6.1 (4.6, 7.8)

6.4 (4.5, 8.3)

 < 0.001

nPNA (g/kg/day)

1.1 ± 0.2

1.1 ± 0.3

1.0 ± 0.2

1.1 ± 0.2

0.460

D/Pcr

0.7 ± 0.2

0.7 ± 0.3

0.7 ± 0.1

0.7 ± 0.2

0.389

Total Kt/Vurea

1.8 ± 0.5

1.8 ± 0.5

1.8 ± 0.4

1.8 ± 0.4

0.246

  1. Abbreviation: nPNA normalized protein nitrogen appearance, D/Pcr dialysate to plasma creatinine concentration ratio, Kt/Vurea urea clearance index