Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis

Table 1 Global Fluid Study: Multivariable Survival Model incorporating interleukin-6 as a continuous covariate (per 1 pg/ml)

Covariates in the Model		Unadjusted Model 1: Il-6 (per pg/ml)			Adjusted Model 2: Il-6 (per pg/ml)
Covariates in the Model		HR	95% CI	p-value	HR	95% CI	p-value
Plasma Il-6 (per 1pg/ml)		1.038	[1.027, 1.05]	< 0.001	1.026	[1.013, 1.039]	< 0.001
Age (per year)					1.05	[1.04, 1.06]	< 0.001
Comorbidities (Stoke/Davies Score)	low	Reference
	medium				1.87	[1.45, 2.4]	< 0.001
	high				2.67	[1.92, 3.71]	< 0.001
Renal clearance (per 10 L/ week)					0.94	[0.9, 0.97]	0.001
Duration of PD (months on Dialysis)					1.01	[1, 1.02]	< 0.001
Albumin (per g/L)					0.94	[0.92, 0.96]	< 0.001
The number of participants		914			868
The number of events		418			402
Observations deleted due to missing data		52			98

ISSN: 1471-2369