parameter | baseline | P value | After 6 months | P value | Changes | P value | |||
---|---|---|---|---|---|---|---|---|---|
zoledronic acid | placebo | zoledronic acid | placebo | zoledronic acid | placebo | ||||
Body mass index, kg/cm2 | 23.72 (4.16) | 23.60 (4.22) | 0.938 | 25.47 (4.54) | 25.98 (4.15) | 0.748 | 1.74 (2.18) | 2.38 (2.35) | 0.445 |
Serum creatinine, mg/dL | 1.33 (0.26) | 1.50 (0.21) | 0.083 | 1.21 (0.15) | 1.32 (0.35) | 0.352 | -0.13 (0.21) | -0.15 (0.32) | 0.870 |
Serum blood urea nitrogen, mg/dL | 42.67 (14.49) | 38.85 (7.79) | 0.396 | 27.67 (9.51) | 30.31 (8.35) | 0.429 | -15.00 (19.31) | -8.53 (8.39) | 0.133 |
Serum potassium, mg/dL | 4.74 (0.91) | 4.90 (1.04) | 0.648 | 4.13 (0.63) | 4.15 (0.57) | 0.947 | -0.60 (0.95) | -0.75 (0.87) | 0.317 |
Hemoglobin, mg/dLa | 11.40 (3.90) | 10.80 (3.10) | 0.645 | 10.30 (2.5) | 10.00 (4.90) | 0.873 | -0.85 (2.75) | -1.00 (3.25) | 0.968 |
Serum calcium, mg/dLa | 8.10 (0.80) | 8.00 (1.00) | 0.467 | 8.25 (0.50) | 8.40 (0.50) | 0.228 | 0.12 (0.62) | 0.50 (0.80) | 0.025 |
Serum phosphorus, mg/dL | 4.63 (1.30) | 4.18 (0.93) | 0.294 | 2.08 (0.67) | 2.16 (0.64) | 0.765 | -2.55 (1.60) | -2.02 (1.11) | 0.317 |
Serum albumin, mg/dL | 3.43 (0.42) | 3.34 (0.57) | 0.607 | 3.33 (0.48) | 3.34 (0.43) | 0.940 | -0.10 (0.29) | 0.00 (0.371) | 0.389 |
Serum alkaline phosphatase, U/La | 207.50 (136.00) | 227.00 (111.00) | 0.889 | 182.50 (98.00) | 248.00 (231.00) | 0.065 | -52.00 (67.50) | 3.00 (169.00) | 0.065 |
Serum parathyroid hormone, ng/La | 311.90 (491.20) | 551.90 (392.8) | 0.085 | 45.53 (71.71) | 80.57 (57.36) | 0.085 | -266.36 (419.46) | -471.32 (335.49) | 0.085 |
Serum vitamin D3, ng/mL | 23.62 (13.55) | 19.73 (11.64) | 0.410 | 55.03 (31.58) | 45.97 (27.12) | 0.410 | 31.41 (18.02) | 26.24 (15.48) | 0.410 |
estimated glomerular filtration rate, ml/min | 59.82 (16.48) | 52.25 (9.13) | 0.114 | 65.15 (12.59) | 62.64 (19.38) | 0.692 | 5.89 (13.36) | 10.92 (15.96) | 0.391 |