Impact of compliance to oral cysteamine treatment on the costs of Kidney failure in patients with nephropathic cystinosis in the United Kingdom

Table 3 Parameters defining reference (log-normal) curves, and associated statistics

Cohort	Event	Mean log (3.d.p.)	Standard deviation log (3.d.p.)	Hazard ratio (2.d.p.)	Median age of onset^a	Mean age of onset (2.d.p.)
Reference case^b	KF	2.684	0.439	1.00	15.00	15.98
Reference case^b	Mortality	3.826	0.362	1.00	46.00	48.77
Poor compliance	KF	2.684	0.439	1.01	15.00	15.40
Poor compliance	Mortality	3.826	0.362	1.00	46.00	48.77
Good compliance^ce	KF	3.062	0.439	0.88	22.00	23.00
Good compliance^ce	Mortality	3.978	0.362	0.96	54.00	56.37

(a) Nearest whole year, (b) Based on Brodin-Sartorius, (c) KF Hazard Ratio (HR) back-calculated using mean age-at-KF from regression, (d) Mortality HR assumed equal to reference, (e) Mortality HR based on expert opinion
Please also note that ‘age of onset’ = time-to-KF (TTK) or time-to-death (TTD)
d.p.: decimal places, KF: Kidney Failure

ISSN: 1471-2369