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Table 4 Resource Inputs and Cost Inputs for post KF management (micro-costing)

From: Impact of compliance to oral cysteamine treatment on the costs of Kidney failure in patients with nephropathic cystinosis in the United Kingdom

Input

Value

Source

% of patients with a living donor transplant

62.34%*

UK Renal Registry 23rd Annual Report [31], (validated by clinical expert as applicable to English setting)

% of patients with a deceased donor transplant

37.66%*

Time on waiting list for transplant (months, range): living donor

0 (0–6) †

National Health Service (NHS) England, 2022 [32],

Time on waiting list for transplant (months, range): deceased donor

24 (24–36) †

Time on waiting list for transplant (months): value used in model

9.04

Calculation: weighted average using living donor % (62.34%) and deceased donor % (37.66%) as weights (validated by clinical expert as applicable to English setting)

Time to transplant rejection or failure (years, range): living donor

22.50 (20.00–25.00) ‡

National Health Service (NHS) England, 2022 [32],

Time to transplant rejection or failure (years, range): deceased donor

17.50 (15.00–20.00) ‡

Time to transplant rejection or failure (years): value used in model

20.62

Calculation: weighted average using living donor % (62.34%) and deceased donor % (37.66%) as weights (validated by clinical expert as applicable to English setting)

% on haemodialysis

88%

UK Renal Registry 23rd Annual Report [31], (validated by clinical expert as applicable to English setting)

% on peritoneal dialysis

12%

Median number of transplants

2

Clinical expert advice

Haemodialysis cost (per month)

£ 2160.78

Weighted average of NHS Reference Costs 2019/20 [33]

Peritoneal dialysis (per month)

£ 2,413.58

Weighted average of NHS Reference Costs 2019/20 [33]

Dialysis cost: value used in model

£ 2,192.12

Calculation: weighted average using % on haemodialysis (88%) and % on peritoneal dialysis (12%) as weights (validated by clinical expert as applicable to English setting)

Kidney transplant – first year (per year)

£ 28,526.52

Kent et al. inflated to 2019/20 [27]

Kidney transplant – subsequent years (per month)

£ 110.93

Kent et al. inflated to 2019/20 [27]

Calculated annual cost inputs based on micro-costing calculations

Good Compliance

£10,329.65

NA, calculation

Poor compliance

£10,329.65

NA, calculation

  1. KF: Kidney Failure, NA; Not Applicable, NHS: National Health service
  2. *These values were based on the UK’ under 16’ population undergoing renal replacement therapy and were scaled up from their original values: 29% and 48% for % with a living donor and deceased donor, respectively
  3. *These values were based on the UK’ under 16’ population undergoing renal replacement therapy and were scaled up from their original values: 29% and 48% for % with a living donor and deceased donor, respectively
  4. † For patients with a living donor transplant, the lower bound provided by the NHS is 3 months, but clinical experts advised that, for this population, it is 0 months in practice as patients are generally treated pre-emptively. For both types of patients, clinical experts suggested the applying the lower bound in the base case
  5. ‡ The ranges were provided by the NHS and the mid-point was assumed in both cases
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BMC Nephrology

ISSN: 1471-2369

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