From: Proteomic analysis investigating kidney transplantation outcomes- a scoping review
Review Category | Inclusion Criteria | Exclusion Criteria | Rationale |
---|---|---|---|
Population | Any human kidney transplant recipients | Animal studies, studies involving other solid organ transplants or bone marrow transplants | Due to studies aims and the varying biological processes and pathology in both animals and other human transplant populations |
Language | Studies from all languages will be included | N/A | Studies written in languages other than research teams’ will be translated using available services at the research centre |
Time period | From inception to present | N/A | Anticipation that most studies will be contemporary given nature of technology |
Study location | All locations included | N/A | Worldwide problem not restricted to a geographical region |
Study Focus | All studies which use any proteomic analysis technique to investigate kidney transplant graft outcome or pathology known to affect kidney transplant function; non exhaustive list rejection, viral infection, medication related injury, delayed graft function, acute kidney injury, prolonged ischaemia | Studies which do not specifically investigate prognostic and/or or diagnostic power of proteomics in kidney transplant grafts | Based on aim of the review |
Sample Type | Any human biological sample including renal biopsy tissue, serum and urine from either donor or recipient, samples used during preparation of kidney transplant | N/A | In keeping with methodology broad range of samples relevant to kidney transplant will be included |
Proteomic techniques | All studies profiling for differential protein expression changes etc. ELISA and western blot data (targeted towards specific candidates), and antibody-based multiplex immunoassays or mass spectrometry-based proteomics (discovery/untargeted proteomics) | N/A | Including targeted and untargeted proteomic techniques allows the review to capture full range of studies in kidney transplant recipients |
Types of Sources | Articles, reviews, books, book chapters, text and opinion papers, web resources—grey literature | N/A | In keeping with scoping review methodology studies of all designs can be included the review including non-published material |