Table 2 Reports of recurrent FG in transplanted kidneys
From: Fibronectin glomerulopathy in a kidney allograft biopsy
Report | Initial diagnosis | Age at initial diagnosis / Sex | Age at ESKD | Recurrence description | Genetic mutations identified | Allograft biopsy EM Histologic |
|---|---|---|---|---|---|---|
Castelletti (2008) [1] | FG by native biopsy | 18 M | 32 | Recurrence in allograft biopsy 3 years post- transplant | NM_212482.4:c.5775G > C (p.Trp1925Cys) NM_212482.3:c.5921T > C(p.Leu1974Pro) NM_212482.2:c.2918A > G(p.Tyr973Cys) | "the deposits were mainly granular" |
Gemperle (1996) [2] | FG by native biopsy | 31 M | 45 | Proteinuria at 7 months post-transplant, allograft biopsy at 23 months post-transplant confirmed recurrence | No genetic mutation identified | "giant subendothelial fibrillary deposits in the allograft" |
Strom (1995) [8] | FG by native biopsy | 31 M | N/A | Recurrence in allograft biopsy | No genetic testing performed | "relapse of deposits" |
Otsuka (2012) [15] | Unknown (no native biopsy performed) | Teenage years F | 49 | Recurrence in allograft biopsy 12 months post-transplant | No genetic testing performed | "electron-dense deposits with microtubular structure measuring 12–14 nm in width" |
Wei (2022) [16] | Mesangial proliferative glomerulonephritis with membranous-like changes by native biopsy | 47 F | 60 | Proteinuria at 27 months post-transplant, allograft biopsy then led to FG diagnosis | NM_212482.3:c.5921T > C(p.Leu1974Pro) | "obscure granular or short fibrillar appearance with a much higher density" |
This case | Type 1 MPGN by native biopsy | 5 M | 17 | Proteinuria noted within months post-transplant, allograft biopsy at 12 years post-transplant led to FG diagnosis | NM_212482.2:c.2918A > G(p.Tyr973Cys) | "massive mesangial and subendothelial electron dense deposit" |