Fig. 1

CT scan and pathological information of the case. a The chest CT scan showed multiple nodules ( ) in both lungs with filling defects ( ) in pulmonary arteries. b The abdominal CT scan showed an enlarged heterogeneous left renal mass ( ) replacing the left kidney and associated tumor thrombus ( ). c-e HE staining showed the tumor cells were organized in a solid sheets pattern (c 10x; d 20x). Large aeras of necrosis and partial myxoid stromal changes (e) were observed. f–h Immunohistochemical staining showed the tumor cells were positive for CD99 (f), WT1 (g) and GATA3 (h). i The fluorescence in situ hybridization assay showed separated red and green signals in the nuclei of 30% of tumor cells. j The next generation sequencing assay displayed a fusion of CIC-LEUTX genes. The breakpoints were at chr19: 42799274 for CIC and chr19: 40276608 for LEUTX, respectively