Table 2 Reported cases of tumors with CIC-LEUTX fusion
Literature /Year | Age/Sex | Location/Size | Diagnosis | IHC | Molecular Change | Status(Month) |
|---|---|---|---|---|---|---|
Huang et al./2016 [6] | 26/Female | Thigh/7.5 cm | Angiosarcomas | Positive: CD31, ERG; Negative: CD99, S100, desmin | CIC-LEUTX | DOD(33) |
Lake et al. /2020 [4] | 19/ Female | Brain/U | Anaplastic ganglioglioma | Positive: synaptophysin, NSE | CIC-LEUTX | AWD(56) |
Lake et al. /2020 [4] | 12/ Female | Brain/U | Anaplastic astrocytoma with epithelioid GBM features | Positive: GFAP, CD34, synaptophysin, | CIC-LEUTX | AWD(3) |
Hu et al. /2020 [3] | 2/Male | Brain/7.5 cm | CNS embryonal tumor | Positive: synaptophysin Negative: GFAP | CIC-LEUTX | AWD(11) |
Song et al. /2022 [5] | 16/Male | Spinal Cord /1.2 cm | CIC-rearranged sarcoma | Positive: CD99, WT1, nestin, synaptophysin, D2-40 | CIC-LEUTX | AWD(5) |
This case | 45/Male | Left kidney/12.2 cm | CIC-rearranged sarcoma | Positive: CD99, WT1, BRG1, GATA3, AE1/AE3; Negative: S-100, Vimtenin, synaptophysin, PAX8, TTF-1 | CIC-LEUTX | DOC(7) |