From: The epidemiology of primary FSGS including cluster analysis over a 20-year period
Variable | Total cohort (n=87) | Immunosuppression (n= 37) | No immunosuppression (n= 50) | P- value | |
---|---|---|---|---|---|
Age | 49.3 (+/- 17.9) | 52.7 (+/- 18.7) | 46.7 (+/- 17.0) | 0.118 | |
Male | 53 (60.9) | 24 (64.9) | 29 (58) | 0.516 | |
White ethnicity | 75 (86.2) | 33 (89.2) | 42 (84) | 0.488 | |
Diabetes | 8 (9.2) | 3 (8.1) | 5 (10) | 0.651 | |
Hypertension | 46 (52.9) | 19 (51.4) | 27 (54) | 0.648 | |
Cardiovascular disease | 13 (15.1) | 3 (8.1%) | 10 (20) | 0.124 | |
Systolic BP at biopsy, mmHg | 130 (120- 140) | 130 (120 -140) | 128 (119 – 135) | 0.627 | |
Diastolic BP at biopsy, mmHg | 79.3 (11.5) | 80.1 (+/-13.2) | 78.7 (+/-10.0) | 0.594 | |
Creatinine, µmol/L | 135 (90-218) | 134 (96.8 – 227) | 134 (88 – 201) | 0.874 | |
eGFR, ml/min/1.73m2 | 46 (27 – 76) | 42.5 (25 – 71.3) | 46 (28.5 – 70) | 0.874 | |
uPCR, mg/mmol | 573 (210 – 811) | 795 (627 – 998) | 318 (193 – 692) | <0.001 | |
Haemoglobin, g/L | 124 (110 – 144) | 118 (104 – 132) | 125 (110 – 153) | 0.012 | |
Corrected calcium, mmol/L | 2.32 (2.24 – 2.42) | 2.30 (2.22 -0 2.39) | 2.37 (2.30 – 2.46) | 0.26 | |
Phosphate, mmol/L | 1.23 (1.05 – 1.37) | 1.30 (1.17 – 1.39) | 1.17 (1.04 – 1.33) | 0.039 | |
Albumin, g/L | 33 (23-41) | 23 (19.5 – 29.3) | 40 (33 – 43) | <0.001 | |
Presented with nephrotic syndrome | 29 (33.3) | 25 (67.6) | 4 (4.6) | <0.001 | |
Remission | Partial | 20 (23) | 8 (21.6) | 12 (24) | 0.794 |
Complete | 43 (49.4) | 23 (62.2) | 20 (40) | 0.041 | |
Combined | 63 (72.4) | 31 (83.8) | 32 (64) | 0.041 | |
Time to remission (days) | 523 (159-1231) | 191 (103.5 – 598) | 806 (255 – 1677) | 0.001 | |
Relapse | 29 (33.7) | 18 (48.6) | 11 (22) | 0.027 | |
ACEi/ ARB | 67 (79) | 28 (75.7) | 39 (78) | 0.799 | |
Immunosuppression | 37 (42.5) | - | - | - | |
RRTa | Total | 24 (27.6) | 10 (27) | 14 (28) | 0.920 |
5 year | 15 (17.2) | 7(18.9) | 8 (16) | 0.722 | |
10 year | 22 (25.3) | 9 (24.3) | 13 (26) | 0.859 | |
Mortalitya | Total | 24 (27.6) | 10 (27) | 14 (28) | 0.920 |
5 year | 9 (10.3) | 5 (13.5) | 4 (8) | 0.404 | |
10 year | 17 (19.5) | 6 (16.2) | 11 (22) | 0.501 | |
Follow up duration, months | 91 (39 – 129) | 99 (37 – 137) | 108 (57.5 – 140) | 0.810 |