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Table 1 Baseline demographics, laboratory values, selected treatment and outcomes for the total cohort, those who received immunosuppression and those who did not

From: The epidemiology of primary FSGS including cluster analysis over a 20-year period

Variable

Total cohort (n=87)

Immunosuppression (n= 37)

No immunosuppression (n= 50)

P- value

Age

49.3 (+/- 17.9)

52.7 (+/- 18.7)

46.7 (+/- 17.0)

0.118

Male

53 (60.9)

24 (64.9)

29 (58)

0.516

White ethnicity

75 (86.2)

33 (89.2)

42 (84)

0.488

Diabetes

8 (9.2)

3 (8.1)

5 (10)

0.651

Hypertension

46 (52.9)

19 (51.4)

27 (54)

0.648

Cardiovascular disease

13 (15.1)

3 (8.1%)

10 (20)

0.124

Systolic BP at biopsy, mmHg

130 (120- 140)

130 (120 -140)

128 (119 – 135)

0.627

Diastolic BP at biopsy, mmHg

79.3 (11.5)

80.1 (+/-13.2)

78.7 (+/-10.0)

0.594

Creatinine, µmol/L

135 (90-218)

134 (96.8 – 227)

134 (88 – 201)

0.874

eGFR, ml/min/1.73m2

46 (27 – 76)

42.5 (25 – 71.3)

46 (28.5 – 70)

0.874

uPCR, mg/mmol

573 (210 – 811)

795 (627 – 998)

318 (193 – 692)

<0.001

Haemoglobin, g/L

124 (110 – 144)

118 (104 – 132)

125 (110 – 153)

0.012

Corrected calcium, mmol/L

2.32 (2.24 – 2.42)

2.30 (2.22 -0 2.39)

2.37 (2.30 – 2.46)

0.26

Phosphate, mmol/L

1.23 (1.05 – 1.37)

1.30 (1.17 – 1.39)

1.17 (1.04 – 1.33)

0.039

Albumin, g/L

33 (23-41)

23 (19.5 – 29.3)

40 (33 – 43)

<0.001

Presented with nephrotic syndrome

29 (33.3)

25 (67.6)

4 (4.6)

<0.001

Remission

Partial

20 (23)

8 (21.6)

12 (24)

0.794

Complete

43 (49.4)

23 (62.2)

20 (40)

0.041

Combined

63 (72.4)

31 (83.8)

32 (64)

0.041

Time to remission (days)

523 (159-1231)

191 (103.5 – 598)

806 (255 – 1677)

0.001

Relapse

29 (33.7)

18 (48.6)

11 (22)

0.027

ACEi/ ARB

67 (79)

28 (75.7)

39 (78)

0.799

Immunosuppression

37 (42.5)

-

-

-

RRTa

Total

24 (27.6)

10 (27)

14 (28)

0.920

5 year

15 (17.2)

7(18.9)

8 (16)

0.722

10 year

22 (25.3)

9 (24.3)

13 (26)

0.859

Mortalitya

Total

24 (27.6)

10 (27)

14 (28)

0.920

5 year

9 (10.3)

5 (13.5)

4 (8)

0.404

10 year

17 (19.5)

6 (16.2)

11 (22)

0.501

Follow up duration, months

91 (39 – 129)

99 (37 – 137)

108 (57.5 – 140)

0.810

  1. ACEi Angiotensin converting enzyme inhibitor, ARB Angiotensin receptor blocker, BP Blood pressure, eGFR Estimated glomerular filtration rate, RRT Renal replacement therapy, uPCR urine protein creatinine ratio
  2. Continuous variables presented as median (interquartile range), unless normally distributed when presented as mean +/- standard deviation, p-value by Mann Whitney-U or ANOVA test. Categorical values presented as number (percentage), p-value by Chi-squared test
  3. a5 and 10-year RRT and Mortality rates are cumulative, 5 year mortality and RRT rates are therefore included within 10 year mortality and RRT rates