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Table 3 Comparison of clinical data of subgroup

From: Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

Variables

PNCI (n = 9)

PCI (n = 19)

t (Z) value

P value

Sex (M/F)

4 / 5

9 / 10

-0.142

0.887

Age (Years)

36.11 ± 11.80

50.32 ± 7.41

-3.905

0.001

Education (Years)

8.00 (8.00, 8.50)

6.00 (3.00, 8.00)

2.335

0.020

BMI (kg/m 2 )

20.42 ± 3.61

22.48 ± 2.42

-1.791

0.085

Hypertension (yes/no)

7 / 2

15 / 3

-0.069

0.945

Diabetes (yes/no)

1 / 8

2 / 17

-0.046

0.963

Cardiovascular disease (yes/no)

5 / 4

11 / 8

-0.378

0.706

Total dialysate glucose content (g/d)

4.50 (4.50, 6.50)

4.50 (7.00, 8.00)

-1.409

0.159

ARB (yes/no)

1 / 8

3 / 15

-0.324

0.746

CCB (yes/no)

6 / 3

14 / 5

-0.377

0.706

β-receptor blocker (yes/no)

2 / 7

7 / 12

-0.760

0.447

TNF-a (pg/ml)

19.50 (18.25, 22.45)

18.80 (16.50, 23.70)

-0.517

0.605

IL-1β (pg/ml)

5.29 (5.00, 21.45)

5.00 (5.00, 6.54)

-1.262

0.207

CRP (mg/L)

0.75 (0.60, 1.08)

1.81 (0.94, 8.97)

-2.533

0.011

WBC (*10 9 /L)

6.21 ± 1.78

7.15 ± 2.26

-1.091

0.285

Scr (mmol/L)

1072.21 ± 295.01

1149.19 ± 264.01

-0.695

0.494

Alb (g/L)

38.92 ± 3.37

36.24 ± 3.77

1.817

0.081

ALT (U/L)

41.44 ± 55.66

23.47 ± 33.05

1.074

0.293

AST(U/L)

20.00 (15.50, 25.00)

18.00 (15.00, 20.00)

-1.087

0.277

TG (mmol/L)

1.22 (1.07, 2.09)

1.62 (0.87, 3.23)

-0.369

0.712

TC (mmol/L)

3.97 (3.36, 6.27)

4.37 (3.76, 5.38)

-0.344

0.731

HDL (mmol/L)

0.98 ± 0.21

1.06 ± 0.26

-0.776

0.445

LDL (mmol/L)

3.04 ± 1.45

2.85 ± 0.93

0.419

0.679

C3 (g/L)

0.84 ± 0.20

1.00 ± 0.11

-2.813

0.009

C4 (g/L)

0.27 ± 0.10

0.38 ± 0.09

-2.738

0.011

PNI

45.32 ± 5.04

42.29 ± 4.56

1.588

0.124

MoCA

27.33 ± 1.22

20.11 ± 3.98

7.220

0.000

MMSE

27.50 (27.00, 30.00)

26.00 (23.00, 28.00)

-2.757

0.006

SAS

35.56 ± 5.90

35.11 ± 7.29

0.201

0.843

SDS

37.11 ± 7.56

36.89 ± 9.20

0.061

0.952

HAMA

6.89 ± 3.89

9.32 ± 5.37

-1.210

0.237

HAMD

4.56 ± 2.96

6.47 ± 3.76

-1.341

0.192

GSRS

26.00 (20.00, 27.50)

22.00 (21.00, 26.00)

-0.322

0.747

  1. Notes: PNI = Alb (g/L) + 5* [total lymphocyte count (*109/L)]; “ARB, CCB and β-receptor blocker” represent the drug used in the previous month. The details of the patients are provided in Table S11
  2. Abbreviations: PNCI Peritoneal dialysis patient with normal cognition, PCI Peritoneal dialysis patient with cognitive impairment, ARB Angiotensin receptor blocker, CCB Calcium channel blockers, BMI Body mass index, TNF-α Tumor necrosis factor-alpha, IL-1β Interleukin-1beta, WBC White blood cell, CRP C-reactive protein, Scr Serum creatinine, Alb Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, TC Total cholesterol, TG Triglyceride, HDL High-density lipoprotein, LDL Low- density lipoprotein, C3 Complement-3, C4 Complement-4, PNI Prognostic nutritional index, MoCA Montreal cognitive assessment scale, MMSE Mini-mental state examination, SAS Self-rating anxiety scale, SDS Self-rating depression scale, HAMA Hamilton anxiety scale, HAMD Hamilton depression scale, GSRS Gastrointestinal symptom rating scale