Correlation between gut microbiome and cognitive impairment in patients undergoing peritoneal dialysis

BMC Nephrology

Table 5 Functional differences analysis

Subgroup	Methods	Change	Pathways	P value
ESRD vs. PD	MetaCyc	Up	Amino Acid Degradation	0.017
		Down	Amino Acid Biosynthesis	0.020
			Antibiotic Resistance	0.029
			Degradation/Utilization/Assimilation – Other	0.008
	Ko_Level 1	Down	Genetic Information Processing	0.032
	Ko_Level 1	Down	Cellular Processes	0.049
	Ko_Level 2	Up	Xenobiotics biodegradation and metabolism	0.017
		Down	Amino acid metabolism	0.002
		Down	Folding, sorting and degradation	0.005
	Ko_Level 3	Up	Selenocompound metabolism	0.025
			Drug metabolism - other enzymes	0.036
			Ascorbate and aldarate metabolism	0.015
		Down	Lysine biosynthesis	0.024
			Protein export	0.002
			Histidine metabolism	0.002
			Glycine, serine and threonine metabolism	0.043
PNCI vs. PCI	MetaCyc	Up	Fatty Acid and Lipid Biosynthesis	0.049
	MetaCyc	Down	Cell Structure Biosynthesis	0.044
	Ko_Level 3	Up	Tyrosine metabolism	0.044
		Down	Pantothenate and CoA biosynthesis	0.049
			Tryptophan metabolism	0.026
			Proteasome	0.027

Notes: “Up” represents a significant increase in the PD (or PCI) group (P < 0.05); “Down” represents significant decrease in the PD (or PCI) group (P < 0.05). The details of the results are shown in Table S7, S8, and S9
Abbreviations: ESRD End stage renal disease, PD Peritoneal dialysis, PNCI Peritoneal dialysis patient with normal cognition, PCI Peritoneal dialysis patient with cognitive impairment, Ko KEGG Ortholog

ISSN: 1471-2369