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Table 5 Clinical parameter outcomes from the two groups in older adults with stage 3–5 CKD

From: Effects of a low-protein nutritional formula with dietary counseling in older adults with chronic kidney disease stages 3–5: a randomized controlled trial

 

Intervention group (n = 24)

Control group (n = 23)

P- valueb

Baseline

3 months

Change in value

(3 months-Baseline)a

Baseline

3 months

Change in value

(3 months-Baseline)a

BUN (mg/dl)

31 (25–43)

29 (22–43)

-2 (-6- -1)

31 (23–46)

26 (19–53)

-2 (-5–1)

0.75

eGFR (mL/min per/1.73 m2)

 MDRD

36 (19–45)

38 (16–44)

-1 (-3–3)

34 (22–50)

31 (19–50)

-1 (-4–1)

0.51

 CKD-EPI (2009)

31 (16–42)

34 (14–39)

-1 (-3–2)

32 (20–46)

28 (17–46)

0 (-4–1)

0.78

 CKD-EPI (2021)

34 (18–46)

37 (15–43)

-1 (-3–3)

34 (22–50)

30 (19–50)

-4 (-1–1)

0.78

 Creatinine (mg/dl)

1.7 (1.6–3.4)

1.7 (1.5–3.7)

0.0 (-0.1–0.3)

1.9 (1.4–3.0)

1.9 (1.4–3.4)

0.1 (-0.1–0.3)

0.35

 LDL (mg/dL)

89 (77–124)

94 (73–134)

-2 (-14–13)

88 (72–115)

82 (70–114)

-2 (-17–10)

0.82

 Triglyceride (mg/dl)

108 (83–164)

120 (77–194)

7 (-12–32)

111 (74–146)

119 (79–143)

0 (-20–22)

0.20

 Albumin (g/dl)

4.2 (4.1–4.4)

4.2 (4.1–4.3)

0.0 (-0.2–0.1)

4.2 (3.9–4.4)

4.2 (3.8–4.4)

0.0 (-0.2–0.1)

0.92

 Hemoglobin (g/dl)

11.8 (10.2–13.7)

12.2 (10.5–13.7)

0.0 (-0.7–0.7)

12.3 (9.8–13.7)

12.1 (9.6–14.0)

-0.4 (-0.9–0.3)

0.30

 ALT (U/L)

18.5 (12.3–21.0)

17.5 (11.3–21.0)

-1.0 (-5.0–2.8)

18.0 (14.0–24.0)

17.0 (14.0–31.8)

0.0 (-3.0–3.5)

0.43

  1. Data are expressed as the median (interquartile range)
  2. BUN blood urea nitrogen, eGFR, estimated glomerular filtration rate, MDRD modification of diet in renal disease, LDL low-density lipoprotein, ALT alanine aminotransferase
  3. aGroups were compared through the Wilcoxon signed-rank test (P < 0.05)
  4. bValue change differences between the two groups as determined by the Mann–Whitney U test