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Table 2 Effect of iron (Fe) administration on blood tests and body weight in adenine-treated rats fed a high-phosphorus diet

From: Effect of iron administration on the aortic iron content and vascular calcification in phosphorus-loaded chronic kidney disease rats

 

Control

No-Fe

PO-Fe

IP-Fe

Na mmol/l

134.8 ± 1.38

136.5 ± 2.5

133.3 ± 3.38

129.8 ± 3.4

K mmol/l

5.7 ± 0.26

3.2 ± 0.2 *1

3.33 ± 0.07 *1

3.10 ± 0.15 *1

Cl mmol/l

98.5 ± 0.65

107 ± 3

104 ± 0.58

101.5 ± 3.93

iCa mmol/l

1.40 ± 0.06

1.10 ± 0.04

1.07 ± 0.06 *1

0.67 ± 0.07 *1,*2,*3

TCO2 mmol/l

29.3 ± 0.63

15.0 ± 1.0 *1

17.3 ± 0.33 *1

12.5 ± 1.04 *1,*3

Glu mg/dL

219.5 ± 9.68

132.0 ± 2.0 *1

144.0 ± 2.5 *1

130.5 ± 10.2 *1

BUN mg/dL

17.3 ± 2.2

115.0 ± 13.0 *1

134.7 ± 5.3 *1

130.5 ± 1.0 *2

Crea mg/dL

0.4 ± 0.0

2.8 ± 0.3 *1

4.1 ± 0.3 *1

2.3 ± 0.2 *1,*3

HCT %PCU

38.8 ± 0.5

28.0 ± 1.0 *1

23.7 ± 2.0 *1

29.8 ± 2.0 *1

Hb g/dL

13.2 ± 0.2

9.6 ± 0.4 *1

8.07 ± 0.7 *1

10.1 ± 0.7 *1

Serum Pi mg/dL

7.1 ± 0.56

22.2 ± 1.5 *1

17.2 ± 0.9 *1

25.5 ± 2.8 *1

Body weight g

581.2 ± 24.5

262.6 ± 1.1 *1

318.3 ± 12.1 *1

242.2 ± 7.1 *1,*3

  1. The No-Fe group, PO-Fe group and IP-Fe group were CKD rats without Fe administration, with peroral Fe administration and with intraperitoneal Fe administration, respectively. Data are expressed as the mean ± SEM and were compared by one-way analysis of variance followed by the Tukey–Kramer test. A two-tailed P < 0.05 was considered statistically significant; *1; p < 0.05 vs. the control group, *2; P < 0.05 vs. the No-Fe group, *3; p < 0.05 vs. the PO-Fe group.
  2. Abbreviations: iCa, ionized calcium; TCO2, total CO2; Glu, glucose; BUN, blood urea nitrogen; Crea, creatinine; HCT, hematocrit; Hb, hemoglobin; Pi, phosphorus.