Adenine model of chronic renal failure in rats to determine whether MCC950, an NLRP3 inflammasome inhibitor, is a renopreventive

Table 1 Summary of the lesion score of the studied groups

Group Lesion	Control -ve	Adenine-induced CRF group	MCC950 treated group
Vacuolar degeneration	-	+ + +	+
Mononuclear cell infiltration	-	+ + +	+ +
Loss of glomeruli architecture	-	+ + +	-
Destruction of Bowman's capsule	-	+ + +	-

- No lesions, + lesions present in 2–3 sections, + + lesions present in 4–7 sections, + + + lesions present in 8–10 sections

ISSN: 1471-2369