Table 3 Association of PENK-A with incident CKD (defined as new eGFR < 60 mL/min/1.73m² plus at least 25% eGFR decline)^a

Range of PENK-A

< 48

48–56

57–70

> 70

Number of events/Number at Risk (%)

 BioMedioR

112/909 (12.3)

135/908 (14.9)

172/909 (18.9)

205/908 (22.6)

624/3634 (17.2)

 Weighted

340/1760 (19.3)

395/1765 (22.4)

472/1756 (26.8)

516/1759 (29.3)

1723/7040 (24.5)

 Model 1*

Reference

1.17 (0.88, 1.53)

1.45 (1.11, 1.88)

1.87 (1.42, 2.45)

1.24 (1.13, 1.37)

< 0.001

 Model 2**

Reference

1.40 (1.05, 1.87)

1.97 (1.49, 2.60)

2.93 (2.18, 3.94)

1.52 (1.35, 1.71)

< 0.001

 Model 3***

Reference

1.12 (0.83, 1.51)

1.32 (0.98, 1.78)

1.43 (1.03, 1.97)

1.15 (1.01, 1.31)

0.03