Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort

Table 5 Association of PENK-A with incident albuminuria^a

	Quartiles of PENK-A
	Q1	Q2	Q3	Q4	Per SD higher	P value⁺
	(OR, 95% CI)	(OR, 95% CI)	(OR, 95% CI)	(OR, 95% CI)	(OR, 95% CI)	P value⁺
Range of PENK-A	< 48	48–58	59–72	> 72
Number of events/Number at Risk (%)
BioMedioR	122/826 (14.8)	124/869 (14.3)	162/877 (18.5)	186/829 (22.4)	594/3401 (17.5)
Weighted	278/1422 (19.5)	275/1414 (19.4)	323/1418 (22.8)	403/1417 (28.4)	1279/5671 (22.6)
Model 1^*	Reference	0.92 (0.66, 1.29)	1.22 (0.89, 1.67)	1.70 (1.25, 2.31)	1.32 (1.17, 1.48)	< 0.001
Model 2^**	Reference	1.00 (0.72, 1.41)	1.39 (1.01, 1.91)	1.98 (1.44, 2.73)	1.41 (1.24, 1.61)	< 0.001
Model 3^***	Reference	0.96 (0.68, 1.36)	1.15 (0.81, 1.62)	1.31 (0.91, 1.90)	1.18 (1.02, 1.37)	0.03

P for interaction for sex: 0.97
P for interaction for race: 0.05
^aWeighted to parent cohort and excluding participants missing PENK-A and baseline albuminuria
^*Adjusted for age, sex, race
^**Adjusted for Model 1 plus body mass index, current smoking, coronary artery disease, systolic blood pressure, use of antihypertensive meds, diabetes mellitus
^***Adjusted for Model 2 plus baseline eGFR and uACR
⁺ P value for SD higher of PENK-A

ISSN: 1471-2369