Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort

Table 6 Association of PENK-A with incident albuminuria stratified by race^a

	PENK-A
	White Participants		Black Participants
	Per SD higher	P-value	Per SD higher	P-value
	(OR, 95% CI)	P-value	(OR, 95% CI)	P-value
Number of events/Number at Risk (%)
BioMedioR	291/1833 (15.9)		303/1568 (19.3)
Weighted	670/3038 (22.1)		607/2633 (23.1)
Model 1^*	1.51 (1.27, 1.80)	< 0.001	1.15 (0.98, 1.36)	0.004
Model 2^**	1.64 (1.35, 1.99)	< 0.001	1.24 (1.03, 1.48)	0.02
Model 3^***	1.32 (1.06, 1.64)	0.02	1.05 (0.85, 1.29)	0.66

^aWeighted to parent cohort and excluding participants missing PENK-A and baseline albuminuria
^*Adjusted for age, sex
^**Adjusted for Model 1 plus body mass index, current smoking, coronary artery disease, systolic blood pressure, use of antihypertensive meds, diabetes mellitus
^***Adjusted for Model 2 plus baseline eGFR and uACR

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