Plasma proenkephalin A and incident chronic kidney disease and albuminuria in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort

Table 7 Association of PENK-A with incident albuminuria stratified by diabetes status^a

	PENK-A
	Without diabetes		With diabetes
	Per SD higher	P-value	Per SD higher	P-value
	(OR, 95% CI)	P-value	(OR, 95% CI)	P-value
Number of events/Number at Risk (%)
BioMedioR	285/2732 (10.4)		115/475 (24.2)
Weighted	956/4584 (20.9)		652/1087 (60)
Model 1^*	1.51 (1.27, 1.80)	< 0.001	1.16 (0.92, 1.46)	0.20
Model 2^**	1.53 (1.31, 1.79)	< 0.001	1.14 (0.90, 1.44)	0.27
Model 3^***	1.29 (1.09, 1.53)	0.02	0.94 (0.70, 1.25)	0.67

P for interaction with diabetes mellitus: 0.03
^aWeighted to parent cohort and excluding participants missing PENK-A and baseline albuminuria
^*Adjusted for age, sex, race
^**Adjusted for Model 1 plus body mass index, current smoking, coronary artery disease, systolic blood pressure, use of antihypertensive meds
^***Adjusted for Model 2 plus baseline eGFR and uACR

ISSN: 1471-2369