Fig. 2
From: The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma
The intricate interplay between MALAT-1 and its downstream targets in renal cell carcinoma (RCC). The aberrant expression of MALAT-1 in RCC has been identified and linked to the advancement of tumors, invasion of surrounding tissues, and the formation of metastases. By functioning as a miRNA sponge and modulating the activity of transcription factors, MALAT-1 disrupts the normal gene expression profiles in RCC cells, thereby fostering the initiation and progression of the disease