From: The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma
MALAT-1 | Results | Ref. | ||
---|---|---|---|---|
Tissue sample/cell line/animal model | Stimulation | Suppression | ||
Human proximal tubule epithelial cells HK-2, 106 primary ccRCC tissues from nephrectomy, Human RCC lines 786- O, ACHN, Caki-1, Caki-2 | … | … | High MALAT-1 expression in both ccRCC tissues and RCC. MALAT-1 promoted RCC proliferation, migration, invasion, and progression. The inhibition of MALAT-1 accelerated apoptosis and induced cell cycle arrest in the G0/G1 phase. Shorter overall survival time in ccRCC patients. | [66] |
50 patients (34 male and 16 female) with clear cell RCC, Normal renal epithelial cells (HK-2), human RCC lines 786-O, A-498, Caki-1, Caki-2 | Ezh2, c-Fos | miR-205 | MALAT-1 by targeting c-Fos and Ezh2, and sponging miR-205 can induce RCC cell proliferation and invasion, and suppress apoptosis. | [68] |
Human tissues, RCC 786-O and Caki-1 cell lines, Six female athymic BALB/c nude mice | Livin | … | High MALAT-1 and the Livin protein in both RCC tissues and the RCC cell lines. MALAT-1 induced proliferation and metastasis. | [71] |
Human RCC cell lines ACHN, 786-O, Caki-1, ccRCC nude mouse | CDC20, AURKA | miR-182-5p, P53 | miR-182-5p reduced MALAT-1 expression. Overexpression of miR-182-5p by targeting MALAT-1 reduced tumor growth. | [72] |
786-O, Caki-1, Ketr-3, RT112, T24, Ect1/E6E7 | PI3K/Akt | miR‑22‑3p | MALAT-1 induced the activation of the PI3K/Akt signaling pathway and suppressed miR-22-3p to promote the proliferation and migration of RCC | [33] |
HK-2, A498, 786-O, OS-RC-2, CAKI-1, HK-2, HEK293T, 786-O, BALB/c nude mice | BIRC5 (survivin) | miR-203 | MALAT-1 by suppressing miR-203, influencing the expression of BIRC5, and promoted cell proliferation, invasion, and migration. | [34] |
786-O, A498, ACHN, BALB/C nude mice | ETS1 | TFCP2L1 | 786-O-EVs, as carriers of MALAT1, played a pivotal role in promoting RCC invasion and metastasis, facilitating the binding of the transcription factor ETS1 to the TFCP2L1 promoter. | [77] |
Tumor and adjacent normal tissue samples from 14 patients with ccRCC | HIF1, ALDOA, miR-122 | miR-1271, SOX-6 | High expression of HIF1 was associated with elevated expression of ALDOA, MALAT-1, mir-122, and low expression of mir-1271 and SOX-6. | [86] |