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Table 1 Baseline continuous variable values in both groups and total

From: The differential effect of modern intravenous iron on fibroblast growth factor 23 and phosphate in non-dialysis dependent CKD – the exploratory randomized controlled double-blind ExplorIRON-CKD study

Variable

Iron group

Value

p-value

Age* / years

Total

67.9 (12.4)

0.043

FDI

63.4 (12.2)

FCM

73.2 (10.8)

Body mass index / kg/m2

Total

27.8 (25.0–33.4)

0.279

FDI

28.8 (26.2–36.3)

FCM

26.8 (23.0–32.7)

iFGF23 / pg/ml

Total

212.1 (145.1–311.6)

0.212

FDI

257.3 (136.2–584.6)

FCM

186.5 (143.6–226.6)

Phosphate / mmol/L

Total

1.28 (1.12–1.43)

0.193

FDI

1.30 (1.16–1.59)

FCM

1.20 (1.07–1.38)

Hemoglobin* / g/L

Total

100.3 (13.5)

0.664

FDI

99.2 (12.2)

FCM

101.6 (15.3)

Serum Ferritin / µg/L

Total

76.5 (38.7–157.5)

0.899

FDI

76.5 (25.0–183.5)

FCM

72.7 (42.3–146.9)

Transferrin saturation / %

Total

15.0 (11.7–18.5)

0.781

FDI

15.0 (11.0–21.0)

FCM

14.5 (12.0–17.8)

Creatinine* / µmol/L

Total

269.5 (88.2)

0.626

FDI

277.6 (98.8)

FCM

260.2 (77.3)

eGFR / ml/min/1.73m2

Total

18.0 (14.0–25.3)

1.000

FDI

18.0 (14.0–25.3)

FCM

18.0 (14.0–25.3)

CRP / mg/L

Total

7.4 (3.3–17.3)

0.462

FDI

8.0 (3.2–20.8)

FCM

4.3 (3.4–13.4)

urinary PCR / mg/mmol

Total

87.5 (30.0–341.3)

0.082

FDI

155.0 (57.5–607.5)

FCM

30.0 (20.0–310.0)

1,25 (OH)2 Vitamin D* / pmol/L

Total

45.6 (22.2)

0.290

FDI

41.3 (20.8)

FCM

50.7 (23.5)

25 (OH)2 Vitamin D / nmol/L

Total

57.4 (22.4–86.0)

0.252

FDI

44.2 (18.3–83.1)

FCM

67.5 (29.9–97.0)

24(R),25 (OH)2 Vitamin D / nmol/L

Total

2.2 (0.6–3.4)

0.631

FDI

1.2 (0.5–4.5)

FCM

2.9 (0.9–3.2)

Calcium* / mmol/L

Total

2.35 (0.08)

0.813

FDI

2.35 (0.08)

FCM

2.34 (0.09)

PTH / pmol/L

Total

17.4 (11.3–22.6)

0.145

FDI

18.9 (12.9–28.8)

FCM

16.3 (7.9–20.9)

24 hr. urinary phosphate / mmol

Total

17.5 (11.0–22.3)

0.023

FDI

21.0 (15.0–23.5)

FCM

12.5 (10.3–17.8)

Fractional excretion of phosphate/ %

Total

43.2 (32.9–55.6)

0.374

FDI

49.7 (32.2–58.3)

FCM

36.4 (32.9–54.5)

ALP / [iU]/L

Total

97.0 (79.0–144.3)

0.667

FDI

96.0 (79.0–153.0)

FCM

107.0 (77.8–129.8)

BALP / [U]/L

Total

19.5 (15.0–26.4)

0.462

FDI

21.3 (16.6–26.8)

FCM

18.7 (14.1–27.5)

CTx / µg/ml

Total

0.89 (0.52–1.07)

0.560

FDI

0.84 (0.56–1.01)

FCM

0.98 (0.49–1.18)

P1NP / µg/L

Total

103.0 (63.0–174.3)

0.820

FDI

112.0 (70.3–178.8)

FCM

103.0 (63.0–166.3)

  1. Variables noted with *: data presented as mean (SD); otherwise data is presented as median (IQR)
  2. p-value represents the statistical significant upon comparison of two groups