Table 4 Concentrations of variables relevant to the 6H syndrome
Visit | Iron group (n) | Mean/Median (SD/IQR) | p-value | p- value (within group analysis) |
|---|---|---|---|---|
iFGF23 | ||||
Baseline | FDI (14) | 257.3 (136.2–584.6) pg/ml | 0.212 | |
FCM (12) | 186.5 (143.6–226.6) pg/ml | |||
1–2 days post 1st infusion | FDI (14) | 251.0 (156.6–583.0) pg/ml | 0.066 | |
FCM (11) | 467.1 (334.6–655.7) pg/ml | |||
2 weeks | FDI (13) | 233.6 (161.0–417.6) pg/ml | 0.410 | |
FCM (10) | 199.7 (144.4–329.1) pg/ml | |||
1 month (2nd infusion) | FDI (12) | 226.5 (137.2–428.9) pg/ml | 0.487 | |
FCM (11) | 212.1 (116.0–253.7) pg/ml | |||
1–2 days post 2nd infusion | FDI (9) | 262.4 (129.1–468.1) pg/ml | 0.035 | |
FCM (10) | 662.7 (375.9–1633.8) pg/ml | |||
2 months | FDI (12) | 301.2 (144.4–533.9) pg/ml | 0.497 | Within FDI: 0.058 |
FCM (10) | 227.8 (165.3–285.3) pg/ml | Within FCM 0.001 | ||
Phosphate | ||||
Baseline | FDI (14) | 1.30 (1.16–1.59) mmol/L | 0.193 | |
FCM (12) | 1.20 (1.07–1.38) mmol/L | |||
1–2 days post 1st infusion | FDI (14) | 1.37 (1.12–1.58) mmol/L | 0.647 | |
FCM (11) | 1.23 (1.04–1.35) mmol/L | |||
2 weeks | FDI (13) | 1.26 (1.05–1.66) mmol/L | 0.049 | |
FCM (10) | 1.09 (0.94–1.23) mmol/L | |||
1 month (2nd infusion) | FDI (12) | 1.18 (1.07–1.57) mmol/L | 0.449 | |
FCM (11) | 1.14 (0.95–1.31) mmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 1.23 (1.15–1.66) mmol/L | 0.065 | |
FCM (10) | 1.11 (0.91–1.36) mmol/L | |||
2 months | FDI (13) | 1.33 (1.13–1.67) mmol/L | 0.057 | Within FDI: 0.278 |
FCM (10) | 1.13 (1.00–1.22) mmol/L | Within FCM: 0.129 | ||
Calcium a | ||||
Baseline | FDI (14) | 2.35 (0.08) mmol/L | 0.813 | |
FCM (12) | 2.34 (0.09) mmol/L | |||
1–2 days post 1st infusion | FDI (14) | 2.39 (0.11) mmol/L | 0.286 | |
FCM (11) | 2.34 (0.10) mmol/L | |||
2 weeks | FDI (13) | 2.36 (0.11) mmol/L | 0.123 | |
FCM (10) | 2.29 (0.06) mmol/L | |||
1 month (2nd infusion) | FDI (12) | 2.35 (0.09) mmol/L | 0.698 | |
FCM (11) | 2.32 (0.08) mmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 2.38 (0.10) mmol/L | 0.063 | |
FCM (10) | 2.31 (0.06) mmol/L | |||
2 months | FDI (13) | 2.35 (0.11) mmol/L | 0.807 | Within FDI: 0.473 |
FCM (10) | 2.36 (0.07) mmol/L | Within FCM: 0.544 | ||
Fractional excretion of phosphate | ||||
Baseline | FDI (14) | 49.7 (32.2–58.3) % | 0.374 | |
FCM (12) | 36.4 (32.9–54.5) % | |||
1–2 days post 1st infusion | FDI (11) | 41.8 (31.4–51.5) % | 0.918 | |
FCM (10) | 41.3 (34.9–50.1) % | |||
2 weeks | FDI (12) | 41.9 (30.2–47.8) % | 0.722 | |
FCM (10) | 40.8 (28.8–53.6) % | |||
1 month (2nd infusion) | FDI (9) | 40.3 (30.1–53.1) % | 0.968 | |
FCM (10) | 42.6 (28.2–53.6) % | |||
1–2 days post 2nd infusion | FDI (8) | 40.1 (27.2–50.2) % | 0.897 | |
FCM (10) | 40.3 (28.2–50.7) % | |||
2 months | FDI (10) | 48.3 (28.5–54.8) % | 0.631 | Within FDI: 0.927 |
FCM (10) | 42.2 (31.0–47.4) % | Within FCM: 0.412 | ||
1,25 (OH)2 Vitamin D a | ||||
Baseline | FDI (14) | 41.3 (20.8) pmol/L | 0.290 | |
FCM (12) | 50.7 (23.5) pmol/L | |||
1–2 days post 1st infusion | FDI (14) | 41.0 (25.6) pmol/L | 0.702 | |
FCM (11) | 44.8 (21.9) pmol/L | |||
2 weeks | FDI (13) | 37.5 (18.6) pmol/L | 0.841 | |
FCM (10) | 39.0 (15.1) pmol/L | |||
1 month (2nd infusion) | FDI (12) | 40.0 (20.5) pmol/L | 0.398 | |
FCM (11) | 47.5 (20.9) pmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 45.8 (42.2) pmol/L | 0.283 | |
FCM (10) | 36.2 (12.6) pmol/L | |||
2 months | FDI (12) | 41.9 (22.2) pmol/L | 0.491 | Within FDI: 0.264 |
FCM (10) | 49.0 (25.3) pmol/L | Within FCM: 0.026 | ||
25(OH)2 Vitamin D | ||||
Baseline | FDI (14) | 44.2 (18.3–83.1) nmol/L | 0.252 | |
FCM (12) | 67.5 (29.9–97.0) nmol/L | |||
1–2 days post 1st infusion | FDI (14) | 44.9 (18.7–83.7) nmol/L | 0.467 | |
FCM (11) | 54.5 (22.1–87.1) nmol/L | |||
2 weeks | FDI (13) | 45.2 (17.3–90.8) nmol/L | 0.832 | |
FCM (10) | 69.0 (22.2–89.8) nmol/L | |||
1 month (2nd infusion) | FDI (12) | 35.7 (15.9–83.7) nmol/L | 0.235 | |
FCM (11) | 68.1 (26.3–102.1) nmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 57.8 (20.5–88.3) nmol/L | 0.604 | |
FCM (10) | 63.3 (25.5–97.0) nmol/L | |||
2 months | FDI (12) | 47.4 (19.2–93.2) nmol/L | 0.346 | Within FDI: 0.945 |
FCM (10) | 70.2 (28.9–112.3) nmol/L | Within FCM: 0.977 | ||
24(R),25 (OH)2 Vitamin D | ||||
Baseline | FDI (14) | 1.2 (0.5–4.5) nmol/L | 0.631 | |
FCM (12) | 2.9 (0.9–3.2) nmol/L | |||
1–2 days post 1st infusion | FDI (14) | 1.2 (0.6–4.2) nmol/L | 0.727 | |
FCM (11) | 2.5 (0.8–3.3)) nmol/L | |||
2 weeks | FDI (13) | 1.2 (0.6–4.3) nmol/L | 0.693 | |
FCM (10) | 3.1 (0.7–3.9) nmol/L | |||
1 month (2nd infusion) | FDI (12) | 1.0 (0.5–3.6) nmol/L | 0.347 | |
FCM (11) | 2.6 (0.7–3.8) nmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 1.7 (0.7–4.1) nmol/L | 1.000 | |
FCM (10) | 2.9 (0.9–3.6) nmol/L | |||
2 months | FDI (12) | 1.3 (0.5–4.8) nmol/L | 0.539 | Within FDI: 0.902 |
FCM (10) | 2.8 (0.9–3.5) nmol/L | Within FCM: 0.406 | ||
PTH | ||||
Baseline | FDI (14) | 18.9 (12.9–28.8) pmol/L | 0.145 | |
FCM (12) | 16.3 (7.9–20.9) pmol/L | |||
1–2 days post 1st infusion | FDI (14) | 16.2 (10.8–27.9) pmol/L | 0.344 | |
FCM (11) | 13.2 (7.2–18.8) pmol/L | |||
2 weeks | FDI (13) | 19.6 (8.3–34.5) pmol/L | 0.564 | |
FCM (10) | 17.2 (10.5–20.1) pmol/L | |||
1 month (2nd infusion) | FDI (12) | 18.2 (7.2–28.4) pmol/L | 0.651 | |
FCM (11) | 17.5 (9.6–22.6) pmol/L | |||
1–2 days post 2nd infusion | FDI (9) | 14.4 (7.4–25.8) pmol/L | 0.604 | |
FCM (10) | 13.4 (7.6–17.5) pmol/L | |||
2 months | FDI (12) | 20.2 (8.9–22.1) pmol/L | 0.283 | Within FDI: 0.299 |
FCM (10) | 12.8 (8.1–20.1) pmol/L | Within FCM: 0.081 | ||