Table 1 Baseline characteristics of individuals stratified by tertiles of SII

Sex, female(%)

743 (44.3)

276 (49.5)

237 (42.3)

230 (41.1)

0.010

Age(years)

50.5 ± 14.0

49.3 ± 14.4

50.3 ± 13.6

52.0 ± 14.0

0.005

Diabetes, n(%)

377 (22.5)

101 (18.1)

129 (23.1)

147 (26.3)

0.004

Hypertension, n(%)

1299 (77.6)

427 (76.7)

425 (76.2)

447 (80)

0.254

Stroke, n(%)

80 ( 9.4)

24 (10.2)

30 (10.4)

26 (7.9)

0.499

CVD, n(%)

199 (23.4)

52 (21.7)

59 (21)

88 (26.6)

0.203

Systolic pressure(mmhg)

144.0 ± 24.1

142.0 ± 22.5

145.3 ± 24.5

144.7 ± 25.2

0.081

Diastolic pressure(mmhg)

85.4 ± 15.1

85.5 ± 15.1

86.1 ± 14.6

84.6 ± 15.7

0.341

Medication

 CCB, n (%)

1221 (78.2)

395 (76.4)

410 (77.1)

416 (81.2)

0.124

 ACEI, n (%)

81 (5.7)

28 (5.9)

21 (4.4)

32 (6.8)

0.265

 ARB, n (%)

564 (38.2)

172 (35.4)

183 (36.6)

209 (42.7)

0.043

 Statin, n (%)

219 (14.9)

53 (10.9)

76 (15.4)

90 (18.5)

0.004

 Aspirin, n (%)

174 (12.0)

37 (7.7)

55 (11.3)

82 (17)

< 0.001

Laboratory variables

 White blood cell(10^9/L)

6.5 ± 2.3

5.1 ± 1.5

6.3 ± 1.7

8.1 ± 2.6

< 0.001

 Platelet(10^9/L)

194.3 ± 80.5

142.8 ± 57.4

192.7 ± 59.7

247.3 ± 84.5

< 0.001

 Hemoglobin(g/L)

89.4 ± 22.1

86.2 ± 22.5

90.2 ± 22.6

91.8 ± 20.8

< 0.001

 Neutrophils(10^9/L)

4.5 ± 2.1

3.1 ± 1.0

4.3 ± 1.3

6.1 ± 2.3

< 0.001

 Monocyte(10^9/L)

0.4 ± 0.2

0.4 ± 0.2

0.4 ± 0.2

0.5 ± 0.2

< 0.001

 Lymphocyte(10^9/L)

1.3 ± 0.5

1.4 ± 0.6

1.3 ± 0.5

1.1 ± 0.4

< 0.001

 Serum creatinine(umol/L)

788.4 ± 318.2

801.2 ± 323.8

797.6 ± 318.1

766.5 ± 312.0

0.133

 Urea nitrogen(mmol/L)

22.4 ± 14.9

23.0 ± 9.6

22.1 ± 9.2

22.1 ± 22.2

0.526

 Albumin(g/L)

36.0 ± 5.7

36.2 ± 5.5

36.3 ± 5.5

35.4 ± 6.1

0.016

 Alkaline phosphatase(U/L)

84.6 ± 61.7

84.3 ± 73.3

82.3 ± 55.1

87.4 ± 55.0

0.374

 Aspartate aminotransferase(U/L)

21.6 ± 15.1

22.1 ± 14.9

21.1 ± 16.4

21.7 ± 14.0

0.489

 Alanine aminotransferase(U/L)

18.9 ± 24.5

20.3 ± 31.1

18.9 ± 23.7

17.5 ± 16.3

0.162

 Total bilirubin(umol/L)

4.9 ± 3.1

5.0 ± 3.5

4.7 ± 2.6

5.0 ± 3.0

0.214

 Cholesterol(mmol/L)

4.5 ± 1.3

4.3 ± 1.2

4.6 ± 1.4

4.7 ± 1.3

< 0.001

 Triglyceride(mmol/L)

1.6 ± 1.2

1.4 ± 0.9

1.7 ± 1.6

1.6 ± 1.0

< 0.001

 High density lipoprotein(mmol/L)

1.2 ± 0.4

1.2 ± 0.4

1.2 ± 0.4

1.2 ± 0.4

0.900

 Low density lipoprotein(mmol/L)

2.8 ± 6.5

2.6 ± 1.0

3.1 ± 1.1

2.8 ± 1.0

0.380

 iPTH(pg/ml)

198.0 (96.6, 351.4)

214.2 (114.3, 361.3)

199.4 (97.7, 352.5)

179.8 (68.1, 338.0)

0.017

 Calcium(mmol/L)

2.1 ± 0.3

2.0 ± 0.3

2.1 ± 0.3

2.1 ± 0.3

< 0.001

 Phosphorus(mmol/L)

1.8 ± 2.8

1.8 ± 0.5

2.0 ± 4.7

1.7 ± 0.6

0.364

 Magnesium(mmol/L)

0.9 ± 0.4

0.9 ± 0.4

0.9 ± 0.3

0.9 ± 0.5

0.369

 sCRP(mg/l)

3.2 (1.3, 8.5)

2.7 (1.2, 5.8)

3.0 (1.2, 6.5)

4.2 (1.6, 12.0)

< 0.001

 Total Kt/V

2.3 ± 1.2

2.3 ± 1.0

2.4 ± 1.7

2.3 ± 0.9

0.420

 RRF(mL/min/1.73m²)

4.1 ± 3.6

3.9 ± 3.2

4.2 ± 3.5

4.1 ± 3.9

0.416

 SII (10^9/L)

611.1 (393.0, 963.0)

316.8 (240.3, 392.4)

610.9 (525.8, 710.4)

1214.0 (963.0, 1696.0)

< 0.001