Association between systemic immune inflammation Index and all-cause mortality in incident peritoneal dialysis-treated CKD patients: a multi-center retrospective cohort study

Table 3 Subgroup analysis for the association of SII stratification and all-cause mortality in PD patients

Variables	Tertiles 1	Tertiles 2		Tertiles 3		P for interaction
Variables	Tertiles 1	HR(95%CI)	p value	HR(95%CI)	p value	P for interaction
Age						0.891
< 65 years	1.00	1.49 (0.79 ~ 2.82)	0.216	2.09 (1.16 ~ 3.76)	0.014
≥ 65 years	1.00	1.07 (0.25 ~ 4.55)	0.929	0.92 (0.26 ~ 3.28)	0.894
Gender						0.310
Male	1.00	0.84 (0.32 ~ 2.21)	0.723	1.49 (0.63 ~ 3.5)	0.362
Female	1.00	1.7 (0.86 ~ 3.37)	0.129	1.88 (1 ~ 3.53)	0.052
Hypertension						0.756
No	1.00	0.82 (0.44 ~ 1.51)	0.524	1.7 (0.97 ~ 2.99)	0.065
Yes	1.00	1.67 (0.96 ~ 2.91)	0.071	1.93 (1.16 ~ 3.22)	0.011
Diabetes						0.925
No	1.00	1.15 (0.63 ~ 2.07)	0.652	1.48 (0.85 ~ 2.59)	0.169
Yes	1.00	1.14 (0.3 ~ 4.29)	0.846	5.62 (1.2 ~ 26.43)	0.029
Pre-existing cardiovascular disease						0.251
No	1.00	1.53 (0.79 ~ 2.94)	0.207	2.54 (1.35 ~ 4.8)	0.004
Yes	1.00	1.95 (0.66 ~ 5.75)	0.226	2.9 (0.88 ~ 9.56)	0.079

Abbreviations: SII systemic inflammatory index, Total Kt/V K, dialyzer clearance of urea; t dialysis time, V volume of distribution of urea, RRF renal residual function, iPTH intact parathyroid hormone, HR hazard ratio, CI confidence interval; adjusted for age, sex, diabetes mellitus, hypertension, strokes, pre-existing cardiovascular disease, drug medication, total Kt/V RRF, hemoglobin, urea nitrogen, Serum creatinine, albumin, cholesterol, triglyceride, High density lipoprotein, Low density lipoprotein, alkaline phosphatase, magnesium, calcium, phosphorus, iPTH aspartate aminotransferase, alanine aminotransferase, total bilirubin

ISSN: 1471-2369