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Table 3 Univariate and multivariate regression for prognostic factors

From: Construction and validation of a prediction model for the risk of citrate accumulation in patients with hepatic insufficiency receiving continuous renal replacement therapy with citrate anticoagulation

Variables

Univariate regression

P-value

Multivariate regression

P-value

0R(95%CI)

estimates

Wald

0R(95%CI)

estimates

Wald

Female

1.808(0.951–3.438)

0.592

3.267

0.071

2.405(1.041–5.556)

0.878

4.223

0.040

Age ≥ 65 years

2.502(1.297–4.825)

0.917

7.492

0.006

    

Weight <63 (kg)

1.124(0.541–2.337)

0.117

0.098

0.755

    

Map <70 mmHg

2.497(0.921–4.807)

0.744

3.110

0.078

    

norepinephrine≥0.1μg/kg/min

2.004(1.311–4.756)

0.915

7.753

0.005

3.005(1.326–6.809)

1.100

6.949

0.008

AST ≥ 127(U/L)

0.76(0.413–1.4)

−0.274

0.774

0.379

    

ALT≥102(U/L)

0.566(0.305–1.05)

−0.568

3.255

0.071

    

Tbil <171umol/L

  

2.159

0.34

    

Tbil 171-342umol/L

0.895(0.432–1.851)

−0.111

0.09

0.764

    

Tbil >342umol/L

1.744(0.755–4.030)

0.556

1.696

0.193

    

PT ≥ 18 s

1.766(0.952–3.274)

0.568

3.255

0.071

    

APPT≥44 s

1.45(0.786–2.676)

0.372

1.413

0.234

    

INR < 1.9

  

8.478

0.014

  

20.321

< 0.001

INR 1.9–2.6

2.029(0.974–4.228)

0.708

3.57

0.059

5.770(2.030–16.400)

1.753

10.813

0.001

INR > 2.6

3.142(1.354–7.285)

1.144

7.104

0.008

14.891(4.237–52.336)

2.701

17.737

< 0.001

PLT <46*10^9/L

1.599(0.865–2.958)

0.47

2.242

0.134

    

CRP ≥ 53.26(mg/L)

0.824(0.447–1.517)

−0.194

0.387

0.534

    

Alb < 33(g/L)

1.016(0.553–1.868)

0.016

0.003

0.959

    

tCa ≥ 2.3 mmol/L

1.490(0.791–2.806)

0.399

1.524

0.217

    

Scr ≥ 168umol/L

1.542(0.838–2.855)

0.436

1.942

0.163

    

BUN≥15 mmol/L

1.255(0.681–2.311)

0.227

0.529

0.467

    

PH ≥ 7.43

1.821(0.983–3.371)

0.599

3.631

0.057

    

PO2 <80 mmHg

3.005(1.308–6.905)

1.1

6.722

0.01

3.971(1.341–11.757)

1.373

6.199

0.013

Lactate≥4(mmol/L)

1.203(0.533–2.716)

0.185

0.198

0.656

    

PCO2 ≥ 35 mmHg

0.732(0.395–1.357)

− 0.312

0.982

0.322

    

Citrate concentration = 1.5 mmol/L

  

7.842

0.049

  

13.060

0.005

Citrate concentration 1.6-2 mmol/L

1.615(0.368–7.096)

0.48

0.403

0.346

5.715(0.813–40.151)

1.743

3.071

0.080

Citrate concentration 2.1–2.9 mmol/L

3(0.736–12.227)

1.099

2.349

0.088

14.892(2.167–102.35)

2.701

7.541

0.006

Citrate concentration ≥ 3 mmol/L

4.21(1.162–15.256)

1.438

4.79

0.025

19.183(3.209–114.678)

2.954

10.484

0.001

Dialysate flow rate ≤ 1000 ml/h

1.861(0.989–3.502)

0.547

3.708

0.054

3.085(1.319–7.212)

1.126

6.758

0.009

constant

    

0.003

−5.978

24.649

< 0.001

  1. MAP mean arterial pressure, Alb albumin, ALT alanine aminotransferase, AST aspartate aminotransferase, Tbil total bilirubin, PLT platelet count, CRP C-reactive protein, PT prothrombin time, INR international normalized ratio, Scr serum creatinine, BUN blood urea nitrogen, tCa total calcium concentration, PO2 partial pressure of oxygen, PCO2 partial pressure of carbon dioxide