Fig. 2

Cox regression model all-cause mortality hazard curves adjusted for covariates characterizing 3-way interactions of eGFR, gender and age category (N = 36,556; years 2013–2019). A Reference is eGFR 90 mL/min/1.73m² in men aged < 65 years. B Reference for men and women is eGFR 90 mL/min/1.73m² aged < 65 years. Model: Elapsed time to all-cause mortality = eGFR + age + gender + eGFR*age + eGFR*gender + age*gender + eGFR*age*gender + covariates. Covariates: ethnicity, living in rental block, smoking, body mass index, lipid medications, hypertension, established CVD, albuminuria, systolic blood pressure, diastolic blood pressure, high-density lipoprotein, low-density lipoprotein, and triglycerides. Restrictive cubic spline was applied to eGFR with knots at 5th, 25th, 75th and 95th percentile. Abbreviations: eGFR, estimated glomerular filtration rate. CVD, cardiovascular disease