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Table 3 Cox regression simplified model (excluding living in rental block) eGFR hazard ratios for all-cause and CVD mortality among patients with type 2 diabetes stratified by age using 65 years as cut-off and gender, with eGFR between 90 and 119 mL/min per 1.73 m2 as reference (N = 36,556; years 2013–2019)

From: Heterogeneity by age and gender in the association of kidney function with mortality among patients with diabetes - analysis of diabetes registry in Singapore

eGFR categories (mL/min per 1.73 m2)

< 65 years

≥65 years

Male

Female

Male

Female

All-cause mortality

    

 < 30

4.97 (1.23, 20.04)

18.22 (7.49, 44.32)

3.26 (2.22, 4.78)

5.73 (4.05, 8.10)

 30 - < 60

1.29 (0.79, 2.13)

2.75 (1.68, 4.51)

1.88 (1.55, 2.28)

2.63 (2.14, 3.22)

 60 - < 90

1.12 (0.88, 1.43)

1.64 (1.19, 2.25)

1.17 (0.98, 1.40)

1.92 (1.59, 2.32)

 90 - < 120

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

CVD mortality

    

 < 30

6.11 (0.84, 44.20)

40.63 (13.09, 126.15)

2.80 (1.35, 5.84)

10.02 (5.44, 18.46)

 30 - < 60

1.51 (0.72, 3.16)

4.03 (1.76, 9.22)

1.87 (1.27, 2.74)

3.87 (2.51, 5.97)

 60 - < 90

1.09 (0.73, 1.65)

1.50 (0.77, 2.95)

1.19 (0.83, 1.72)

2.22 (1.46, 3.37)

 90 - < 120

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

  1. Model: Elapsed time to all-cause/CVD mortality = eGFR + age + gender + eGFR*age + eGFR*gender + age*gender + eGFR*age*gender + covariates. Covariates: ethnicity, smoking, body mass index, lipid medications, established CVD, albuminuria. Abbreviations: eGFR estimated glomerular filtration rate, CVD cardiovascular disease