Table 1 Demographic and pharmacokinetic parameters used in PK models

Body weight (kg)

88 ± 26 [40–177]¹³

Volume of distribution (L/kg)

0.45 ± 0.25 [0.25–1.11]^14–17

0.29 ± 0.20 [0.17–1.10]^18–21

0.36 ± 0.15

[0.11–0.75]^22–28

0.39 ± 0.18

[0.08–1.07]^31–36

0.4 ± 0.21

[0.12–1.72]^38–40

0.5 ± 0.37 [0.11–2.13]⁴⁰

Unbound fraction of drug

0.79 ± 0.09

[0–1]¹⁶

0.86 ± 0.08

[0–1]²⁰

0.80 ± 0.16

[0–1]²⁹

0.98 ± 0.16

[0–1]³⁷

0.81 ± 0.10

[0–1]⁴⁰

0.74 ± 0.27

[0–1] ⁴⁰

Non-renal clearance (mL/min)

24.6 ± 19.4

[0-66.8]^14–16

20.8 ± 7

[10.1–37.7] ^18–21

89.2 ± 31.9

[27.1–160.0]^24–28,30

38.3 ± 25.6

[0-104.8]^32,34,36

45.7 ± 38.3

[0-192.0]^38,40,41

38.3 ± 66.2

[0-381.0] ^38–40

SA

Qd = 300 ml/min

0.45 ± 0.09

[0–1]^{14–17,42−44}

0.34 ± 0.06

[0–1] ^18–21,45

0.34 ± 0.07

[0–1]^{22–28,30,46–48}

0.37 ± 0.07

[0–1]^{31–36,49−54}

0.31 ± 0.06

[0–1]^{38,41,55–63}

0.33 ± 0.07

[0–1]^{38,55–57,61,63,64}

Qd = 100 ml/min

0.68 ± 0.14

[0–1] ^{14–17,42−44}

0.58 ± 0.11

[0–1] ^18–21,45

0.63 ± 0.12

[0–1] ^{22–28,30,46–48}

0.65 ± 0.13

[0–1] ^{31–36,49−54}

0.46 ± 0.09

[0–1]^{38,41,55–63}

0.51 ± 0.10

[0–1] ^{38,55–57,61,63,64}

Qd = 50 ml/min

0.75 ± 0.15

[0–1] ^{14–17,42−44}

0.73 ± 0.15

[0–1] ^18–21,45

0.82 ± 0.16

[0–1] ^{22–28,30,46–48}

0.83 ± 0.16

[0–1] ^{31–36,49−54}

0.55 ± 0.11

[0–1] ^{38,41,55–63}

0.63 ± 0.13

[0–1]^{38,55–57,61,63,64}

SC

Quf = 5 ml/min

0.82 ± 0.16

[0–1] ^{14–17,42−44}

1.0 ± 0.20

[0–1] ^18–21,45

0.82 ± 0.16

[0–1] ^{22–28,30,46–48}

0.98 ± 0.2

[0–1] ^{31–36,49−54}

0.87 ± 0.17

[0–1] ^{38,41,55–63}

1.0 ± 0.20

[0–1] ^{38,55–57,61,63,64}