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Table 3 Follow-up data for patients treated with corticosteroid therapy

From: Use of corticosteroids in Norwegian patients with immunoglobulin a nephropathy progressing to end-stage kidney disease: a retrospective cohort study

 

Corticosteroid group (n = 40)

ESKD (yes)

40 (100)

RAS blockade (yes)

38 (95)

UACR (mg/mmol) before RAS blockade

508 (248–717)

UACR (mg/mmol) after RAS blockade

210 (133–536)

eGFR (mL/min/1.73 m2) before corticosteroid treatment

21 (13–46)

eGFR (mL/min/1.73 m2) immediately after corticosteroid treatment

20 (12–40)

 ≥ 50% decrease in eGFR during treatment

5 (13)

 ≥ 50% decrease in eGFR from diagnosis until immediately after corticosteroid treatment

17 (43)

eGFR (mL/min/1.73 m2) immediately after corticosteroid treatment

 > 90

2 (5.0)

60–89

1 (3)

45–59

5 (13)

30–44

8 (20)

 < 30

24 (60)

Proteinuria (g/24 h) before corticosteroid treatment

5.5 (3.4–7.3)

Proteinuria (g/24 h) immediately after corticosteroid treatment

3.0 (1.8–5.2)

Reduction in proteinuria (g/24 h) during corticosteroid treatment

1.9 (0.9–3.4)

Adverse effects

None

5 (13)

Mild

26 (65)

Severe

9 (23)

  1. For quantitative variables, values are expressed as medians (interquartile ranges), and for qualitative variables, values are expressed as n (%)
  2. Adverse effects are divided into three categories: none, mild or severe. The adverse effect is considered severe if the patient needed to be hospitalized due to the adverse effect
  3. ESKD end-stage kidney disease, RAS Renin-angiotensin system, eGFR estimated glomerular filtration rate