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Table 4 Adjusted hazard ratios among ADPKD patients overall

From: Mortality risk in patients with autosomal dominant polycystic kidney disease

Non-ESRD CKD

ESRD

Characteristic

Category

Adjusted HR (95% CI)

P value

Characteristic

Category

Adjusted HR (95% CI)

P value

Stage

Stage 1

0.38 (0.08–1.89)

0.2351

Treatment

Dialysis

2.36 (2.23–2.50)

 < 0.0001

Stage 2

0.79 (0.40–1.54)

0.4898

Transplant

Reference

N/A

Stage 3

Reference

N/A

Stage 4

1.59 (1.11–2.26)

0.0105

Stage 5

2.71 (1.32–5.53)

0.0063

Age group

 < 35 years

0.53 (0.03–8.44)

0.6567

Age group

 < 18 years

0.15 (0.02–1.05)

0.0562

18–24 years

0.19 (0.08–0.45)

0.0002

25–34 years

0.18 (0.12–0.27)

 < 0.0001

35–44 years

0.79 (0.15–4.12)

0.7842

35–44 years

0.20 (0.16–0.24)

 < 0.0001

45–54 years

0.24 (0.05–1.28)

0.0952

45–54 years

0.28 (0.25–0.30)

 < 0.0001

55–64 years

0.89 (0.40–1.95)

0.7654

55–64 years

0.48 (0.45–0.52)

 < 0.0001

65–74 years

Reference

N/A

65–74 years

Reference

N/A

75–84 years

1.70 (1.13–2.56)

0.0112

75–84 years

1.75 (1.62–1.90)

 < 0.0001

85 years and older

3.45 (2.28–5.23)

 < 0.0001

85 years and older

2.77 (2.44–3.14)

 < 0.0001

Sex

Female

0.76 (0.55–1.05)

0.0976

Sex

Female

0.91 (0.86–0.96)

0.0006

Male

Reference

N/A

Male

Reference

N/A

Race

Black

1.20 (0.77–1.88)

0.4185

Race

Black

0.92 (0.85–1.00)

0.0492

Hispanic

1.29 (0.37–4.49)

0.6910

Hispanic

0.71 (0.64–0.79)

 < 0.0001

Asian

1.55 (0.65–3.71)

0.3261

Asian

0.63 (0.52–0.76)

 < 0.0001

Other or unknown a

0.57 (0.16–2.01)

0.3787

Other or unknown a

0.88 (0.66–1.18)

0.4013

White

Reference

N/A

White

Reference

N/A

  1. ADPKD Autosomal dominant polycystic kidney disease, CI Confidence interval, CKD Chronic kidney disease, ESRD End-stage renal disease, HR hazard ratio, N/A Not applicable, USRDS United States Renal Data System
  2. Notes: Adjusted HRs were estimated from the Cox model, including treatment, age group, sex, and race. Age and treatment were determined at study entry (start of patient-time at risk)
  3. aIn addition to “White,” “Black,” “Hispanic,” and “Asian” in the non-ESRD CKD USRDS dataset, “race” also included “Native American,” “Other,” and “Unknown,” which have been grouped in this table as “Other or unknown.” In addition to “White,” “Black/African American” (referred to as “Black” in this table), “Hispanic,” and “Asian” in the ESRD USRDS dataset, “race” also included “American Indian or Alaska Native,” “Native Hawaiian or Pacific Islander,” “Other or Multiracial,” and Unknown, which have been grouped in this table as “Other or unknown.”
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BMC Nephrology

ISSN: 1471-2369

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