Table 2 Baseline Characteristics: Vital signs and Biomarkers in hospitalized COVID-19 patients

n

128

22

106

Age (y) ^a

58.1 ± 14.5

64.2 ± 14.7

56.8 ± 14.2

.031 ^b

Sex, % male (n)

57.0 (73)

68.2 (15)

54.7 (58)

.344 ^c

Vital signs at admission to ED

 Heart rate (b.p.m.) ^a

88 ± 15.9

94 ± 18.4

87 ± 15.1

.074 ^d

 Systolic blood pressure (mmHg) ^a

130 ± 20.3

130 ± 23.3

130 ± 19.7

.960 ^d

 Diastolic blood pressure (mmHg) ^a

82 ± 16.9

77 ± 17.3

83 ± 16.7

.177 ^d

 Oxygen demand, % (n)

53.9 (69)

63.6 (14)

51.9 (55)

.355 ^c

 Respiratory rate (/min) ^a

23 ± 6.0

26 ± 6.2

22 ± 5.8

.007 ^d

 NEWS-2 ^e

4 (2–6.75)

7 (4–9)

4 (2–6)

 < .001 ^b

Biomarkers

 bio-ADM (pg/ml) ^e

37.8 (26.6–56.2)

60.0 (46.0–105.9)

35.0 (23.7–50.0)

 < .001 ^b

 IL-6 (pg/ml) ^e

39.5 (18.5–77.1)

111.0 (61.7–288.0)

33.9 (16.9–61.3)

 < .001 ^b

 bio-ADM*IL-6 (pg/ml x pg/ml) ^e

1610.3 (560.0–3817.4)

9807.0 (2847.4–32,699.1)

1103.0 (502.1–2437.7)

 < .001 ^b

 Serum creatinine (mg/dl) ^e

0.93 (0.77–1.31)

1.18 (1.00–1.57)

0.88 (0.74–1.20)

 < .001 ^b

 dpp3 (ng/ml) ^e

21.5 (16.0–32.8)

31.6 (20.0–54.1)

19.4 (15.2–30.0)

.004 ^b

 hsTnT (ng/l) ^e

9.2 (5.8–16.7)

26.3 (13.1–54.5)

8.6 (5.4–13.7)

 < .001 ^b

 NT-proBNP (pg/ml) ^e

104.5 (50.0–390.8)

699.0 (134.8–3144.0)

75.0 (50.0–291.3)

 < .001 ^b

 White blood cell count (n/nl) ^e

5.74 (4.15–7.96)

7.25 (4.99–11.71)

5.50 (4.02–7.43)

.010 ^b

 CRP (mg/dl) ^e

52.7 (24.8–96.4)

117.5 (63.9–163.0)

44.9 (22.0–82.5)

 < .001 ^b

 Procalcitonin (ng/ml) ^e

0.09 (0.06–0.18)

0.30 (0.11–0.44)

0.08 (0.06–0.14)

 < .001 ^b