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Fig. 1 | BMC Nephrology

Fig. 1

From: Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker

Fig. 1

Physiological parameters and oxidized albumin validation study of rats. (a)Body weight. Rats in high-salt diet group had increased body weight compared to normal-salt group. (b)Weight of residual kidney. Weight of residual kidney showed no significant difference among groups after 4-week treatment. (c)Weight of residual left ventricle. weight of residual left ventricle was higher in high-salt group rats compared to normal-salt group rats. (d)Water intake. High-salt group rats exhibited significantly higher water intake compared to normal-salt group rats. (e)Urine volume. High-salt group rats exhibited significantly higher urine volume compared to normal-salt group rats. (f)Food intake. High-salt group rats exhibited significantly lower food intake compared to normal-salt group rats. (g)Systolic Blood Pressure. Rats in high salt diet group had significantly elevated systolic blood pressure compared to normal salt group. Tempol loading improved systolic blood pressure. (h)Urinary Protein. After high-salt treatment, urinary protein level in high-salt diet group was significantly higher than that in normal-salt diet group. After Tempol loading, urinary protein level decreased. (i)Oxidized Albumin. The high-salt diet group had significantly higher serum oxidized albumin level compared to normal-salt diet group. Administration of Tempol effectively reversed the impact of high salt loading, resulting in reduced serum oxidized albumin level.The values are shown as AVE ± SEM

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BMC Nephrology

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