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Fig. 6 | BMC Nephrology

Fig. 6

From: Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker

Fig. 6

Tempol attenuates renal inflammation and renal fibrogenic pathways in high-salt diet group. Real-time PCR was employed to analyze the gene expression of TNF-α, IL-6, and MCP-1 in rats. TNF-α(a), IL-6 (b) and MCP-1(c) expression were significantly attenuated by Tempol treatment following a notable increase in mRNA level induced by high salt loading. In the High-salt diet group of rats, renal TGF-β1(d), Smad3(e) and p65-NF-κB(f) mRNA levels were significantly increased compared to Normal diet rats. However, in Treatment group, renal TGF-β1, Smad3 and p65-NF-κB mRNA levels were notably decreased compared to High-salt diet group. The values are shown as AVE ± SEM

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BMC Nephrology

ISSN: 1471-2369

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